Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) Study

项目摘要 小温贝托·帕拉达博士是圣地亚哥州立大学流行病学终身教授 加州大学圣地亚哥分校(SDSU)和加州大学圣地亚哥分校(UCSD)穆尔斯癌症 中心。帕拉达博士在北卡罗来纳大学教堂山分校获得流行病学博士学位 (UNC)2016年。作为一名癌症流行病学家，帕拉达博士的研究目标是确定环境， 影响乳房发育和进展的行为(包括饮食)和遗传因素 癌症是最常见的癌症，也是与癌症相关的死亡的第二大原因 在美国(US)的女性，为了完善降低风险的策略，以减轻乳房负担 国内和国际上的癌症。他的建议题为“红细胞多不饱和脂肪酸和 女性健康饮食和生活(WHEL)研究中的乳腺癌死亡率“寻求调查，使用 结构模型，红色测量的四种ω-3和四种ω-6多不饱和脂肪酸之间的关系 乳腺癌后的血细胞(RBC)和死亡率以及乳腺肿瘤样本中的基因表达。到目前为止， 少数几项检查脂肪酸与乳腺癌死亡率的流行病学研究依赖于自身 报告的评估，容易受到测量误差的影响。生物标记物测量方法的使用 新的分析方法将使帕拉达博士能够客观和更准确地估计两者之间的联系 这八种多不饱和脂肪酸与乳腺癌死亡率之间的关系。此外，虽然实验室 使用乳腺癌细胞的研究和动物研究已经确定了脂肪酸 可能会影响癌症的发生和发展，但还没有研究发现脂肪酸与基因表达有关 在乳腺肿瘤样本中。记录RBC脂肪酸与乳腺癌死亡率之间的关系 将有助于为被诊断为乳腺癌的女性提供饮食摄入指南。 拟议的职业发展和培训计划包括三个培训目标，以加强博士。 帕拉达成为一名独立研究员的轨迹：1)接受营养科学和 与营养有关的癌症研究，2)发展技术、分析和概念方法方面的专门知识 生物标志物，以及3)提高技能，参与职业发展机会。这 项目将在SDSU和UCSD在他的指导团队的指导下进行，该团队具有以下专业知识 乳腺癌流行病学(主要导师：M.Elena Martinez，博士)、饮食/营养(共同导师：Cheryl L. Rock，Phd，RD)，环境健康(共同导师：Eunha Hoh，PhD)，分子流行病学(共同导师： Melissa A.Troester博士)和生物统计学(合作者：Mingan Yang，博士)。

Project Summary Humberto Parada Jr, PhD, is tenure-track Assistant Professor of Epidemiology at San Diego State University (SDSU) and Associate Member of the University of California, San Diego (UCSD) Moores Cancer Center. Dr. Parada received his Ph.D. in epidemiology from the University of North Carolina at Chapel Hill (UNC) in 2016. As a cancer epidemiologist, Dr. Parada’s research goals are to identify environmental, behavioral (including dietary), and genetic factors that influence the development and progression of breast cancer, the most frequently diagnosed cancer and the second leading cause of cancer-related death among women in the United States (US), in order to refine risk reduction strategies to reduce the burden of breast cancer nationally and internationally. His proposal entitled “Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women’s Healthy Eating and Living (WHEL) Study” seeks to investigate, using structural models, the associations between four ω-3 and four ω-6 polyunsaturated fatty acids measured in red blood cells (RBC) and mortality following breast cancer and gene expression in breast tumor samples. To date, the few epidemiologic studies that have examined fatty acids and breast cancer mortality have relied on self- reported assessments, which are subject to measurement error. The use of a biomarker measure together with novel analytical methods will allow Dr. Parada to objectively and more accurately estimate the associations between these eight polyunsaturated fatty acids and breast cancer mortality. Furthermore, while laboratory studies using breast cancer cells and animal studies have identified important mechanisms by which fatty acids may impact carcinogenesis and progression, no studies have examined fatty acids relative to gene expression in breast tumor samples. Documenting the associations between RBC fatty acids and breast cancer mortality would help to inform dietary intake guidelines among women diagnosed with breast cancer. The proposed career development and training plan includes three training goals to enhance Dr. Parada’s trajectory toward becoming an independent investigator: 1) Obtain training in nutrition science and nutrition-related cancer research, 2) Develop expertise in technical, analytic and conceptual approaches for biomarkers, and 3) Improve skills in grantsmanship and participate in career development opportunities. This project will be carried out at SDSU and UCSD under the guidance of his mentoring team with expertise in breast cancer epidemiology (Primary mentor: M. Elena Martinez, PhD), diet/nutrition (Co-mentor: Cheryl L. Rock, PhD, RD), environmental health (Co-mentor: Eunha Hoh, PhD), molecular epidemiology (Co-mentor: Melissa A. Troester, PhD), and biostatistics (Collaborator: Mingan Yang, PhD).