Core I: Latino Core

抽象-拉丁裔核心 拉丁裔核心的总体目标是支持高质量、尖端的病因学研究项目， 阿尔茨海默病和相关痴呆的发病机制、诊断、治疗和预防 提供数据和生物标本，来自最初注册的特征良好、纵向关注的拉丁裔 没有来自社区的痴呆症。拉美裔比非拉丁裔白人患ADRD的风险更大，但这一领域 一直在努力让这些人参与临床研究。回应国家适应行动方案在健康方面的里程碑 差异/公平，我们的拉丁裔核心将支持评估流行病学和机械性途径的研究 了解ADRD在卫生负担方面的差异，并促进与我们的 不同的参与者使用因地制宜的方法和研究努力来了解和促进 关于差异的科学。尽管存在包括拉丁裔在内的大型、富有成效的研究，但在这方面的进展 菲尔德一直受到脑组织严重缺乏的阻碍，这些脑组织特征良好的拉丁裔老年人没有 痴呆症。此外，关于认知衰退和从正常衰老到轻度衰老的转变的数据有限 拉美裔老年人中的认知障碍(MCI)和痴呆症；很少有研究检查血液 不同种族/民族的生物标记物差异。建立在我们成功的历史和与 服务不足的社区，拉丁裔核心准备填补我们知识基础中的关键空白，并加快 通过提供资源来研究健康差距，包括参与者、临床数据和事前-以及 死后生物标本以支持广泛的研究--特别是那些历史上 来自不同群体的数据有限(例如，神经成像、基因组学、表观基因组学、蛋白质组学和 代谢组学)。

ABSTRACT – LATINO CORE The overall goal of the Latino Core is to support high quality, cutting edge, research projects on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer’s disease and related dementias (ADRD) by providing data and biospecimens from well-characterized, longitudinally followed Latinos who initially enroll without dementia from the community. Latinos are at greater risk of ADRD than non-Latino Whites, but the field has struggled to engage this population in clinical research. In response to the NAPA milestones on health disparities/equity, our Latino Core will support studies that assess the epidemiology, and mechanistic pathways of disparities in health burden of ADRD, and facilitate engagement, understanding, and partnership with our diverse participants using culturally-tailored approaches and research efforts to understand and advance the science of disparities. Despite the existence of large, productive studies that include Latinos, progress in the field has been hampered by a critical lack of brain tissue from well characterized older Latinos without dementia. Moreover, there is limited data regarding cognitive decline and transitions from normal aging to mild cognitive impairment (MCI) and dementia among older Latinos; and few studies have examined blood biomarker differences across race/ethnicity. Building on our history of success and experience working with underserved communities, the Latino Core is poised to fill a critical gap in our knowledge base, and accelerate research in health disparities by providing resources, including participants, clinical data, and ante- and postmortem biospecimens to support a wide range of research studies – particularly those that historically have had limited data from diverse groups (e.g., neuroimaging, genomics, epigenomics, proteomics, and metabolomics).