Clinical Core

项目摘要-临床核心(CC) 加州大学戴维斯分校阿尔茨海默病研究中心(UCD ADRC)的使命是推动 在不同人群中健康的大脑老化，同时照顾那些受痴呆症影响的人。这项任务和 临床核心(CC)的工作为国家制定的许多里程碑和目标做出了贡献 阿尔茨海默病计划(NAPA)。CC对UCD ADRC的使命至关重要，部分原因是维持 纵向多样性队列(LDC)是一个庞大的、高度多样化的老年人群体，每年都会通过 进行尸检，并监督从这些个人获得的多个数据来源的收集工作。这 队列在ADRC中非常独特，因为它包括来自两个 美国最大的代表性不足的群体：非裔美国人(约占队列的25%)和拉美裔(约25%)。 这种多样性转化为认知轨迹、阿尔茨海默病事件和相关因素的异质性 痴呆(ADRD)、危险因素和生活经历，以及血管危险因素的患病率 与社区人群一致，从而为研究AD和混合型提供了宝贵的资源 病理学。样本在教育程度(0-20年)、母语、 社会经济和移民地位，以及遭遇逆境。主要通过社区招募， UCD ADRC招募认知正常和轻度受损的人来研究认知衰退和 过渡到疾病的不同阶段。这有助于识别新的可更改风险和保护 因素和生物标记物的发展，这两者都对痴呆症的预防有意义。中的所有个人 最不发达国家的特征是异常丰富的水平(远远超过UDS)，包括神经成像和 血液生物标记物，年度诊断分类，认知和心理测量的严格测量 日常功能(与用于诊断的测量分开)和广泛的生命周期收集 社会文化和行为数据。最不发达国家是一个建立良好的队列，拥有来自两个活跃的 (n=425)和非活动性病例(n&gt；950)，其中一些有15年以上的随访。所有这些数据都已集成到 UCD ADRC数据库，提供了一个被研究人员广泛使用的易于访问的研究资源 无论是在我们的中心内外。来自最不发达国家的数据有助于创新的新研究成果 在许多领域，包括加强我们对认知老龄化方面的民族/种族差异的了解，以及 在许多其他贡献中，血管疾病对大脑健康的贡献。此外，消委会还拥有 与流行病学研究建立双向翻译关系的额外优势 认识ADRD的复杂决定因素加速开发有效的治疗方法 以及整个ADRD范围内的预防。

PROJECT SUMMARY - Clinical Core (CC) The mission of the UC Davis Alzheimer’s Disease Research Center (UCD ADRC) is to advance the science of healthy brain aging among diverse populations while caring for those affected by dementia. This mission and the work of the Clinical Core (CC) contribute to many of the milestones and goals set forth by the National Alzheimer’s Disease Plan (NAPA). The CC is essential to the UCD ADRC’s mission, in part, by maintaining the Longitudinal Diversity Cohort (LDC), a large, highly diverse group of older adults followed annually through autopsy, and by overseeing the collection of the multiple sources of data obtained from these individuals. This cohort is highly unique among ADRCs in that it includes substantial numbers of older adults from two of the largest underrepresented groups in the U.S.: African Americans (~25% of the cohort) and Hispanics (~25%). This diversity translates into heterogeneity of cognitive trajectories, incident Alzheimer’s disease and related dementias (ADRD), risk factors and lifecourse experiences, and the prevalence of vascular risk factors consistent with community populations, thereby providing a valuable resource for studying both AD and mixed pathologies. The sample is similarly diverse in terms of education (range of 0-20 years), native language, socioeconomic and immigration status, and exposure to adversity. Through primarily community recruitment, the UCD ADRC enrolls cognitively normal and mildly impaired individuals to study cognitive decline and the transition to various stages of disease. This facilitates identification of novel modifiable risk and protective factors and biomarker development, both of which have implications for dementia prevention. All individuals in the LDC are characterized at an uncommonly rich level (well beyond the UDS) that includes neuroimaging and blood biomarkers, annual diagnostic classification, psychometrically rigorous measurement of cognition and daily function (separate from measurements used for diagnosis) and extensive collection of lifecourse sociocultural and behavioral data. The LDC is a well established cohort with extensive data from both active (n=425) and inactive cases (n>950), some with 15+ years of follow-up. All of this data has been integrated into the UCD ADRC database that provides an easily accessible research resource widely utilized by researchers both within and outside of our Center. Data from the LDC has contributed to innovative new research findings in many areas including enhancing our understanding of ethnic/racial disparities in cognitive aging and the contributions of vascular disease to brain health, among many other contributions. In addition, the CC has the added advantage of creating bi-directional translational relationships with epidemiological studies aimed at understanding the complex determinants of ADRD and accelerating the development of effective treatment and prevention across the ADRD spectrum.