EVENT RELATED POTENTIALS IN OLDER SCHIZOPHRENIA PATIENTS

老年精神分裂症患者的事件相关潜力

• 批准号: 2621955
• 负责人: John M Olichney
• 金额: $ 7.41万
• 依托单位: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2621955
• 关键词: aging; biomarker; brain electrical activity; clinical research; cognition disorders; evoked potentials; hippocampus; human middle age (35-64); human old age (65+); human subject; hypothalamus; language disorders; magnetic resonance imaging; neuropathology; schizophrenia; semantics

DESCRIPTION (Adapted from applicant's abstract): Specific Aims: To examine the P300 and N4OO Event-Related Potentials (ERPs) in a well-characterized cohort of older schizophrenia patients, with comparably aged samples of patients with late-onset schizophrenia (LOS) and early- onset schizophrenia (EOS). P300 and N400 abnormalities will each be related to specific clinical, neuropsychological. and neuroanatomical (ME volumetry) measures. if, as we hypothesize, different patterns of ERP abnormalities are found in EOS and LOS, this win advance our understanding of "the schizophrenias",(i.e. a likely heterogenous group of disorders). Our preliminary data suggest relative sparing of the P300 amplitude in LOS, while the N400 latency is somewhat more delayed in LOS than in E05. Main Hypotheses: I) The P300 amplitude will be reduced in EOS patients, compared to age-matched normal controls and LOS patients. Smaller P300 amplitudes will be related to impairment in attention and learning, and to smaller hippocampal and thalamic volumes. 2) N40O amplitude reductions will occur predominantly in EOS patients. The N400 amplitude will be reduced in patients characterized by more severe negative symptoms (especially poverty of thought and alogia) and abnormal language abilities. The secondary hypotheses include: Schizophrenia patients with abnormal cognitive ERPs (P300 or N400) will have poorer global cognitive function than patients with normal ER Pg. Methods: Thirty subjects from each group (EOS, LOS, controls) will be selected from the UC San Diego Geropsychiatry Clinical Research Center with comparable age, education, ethnicity and gender. All subjects will have had undergone recent clinical assessment (within 7 days), MRI scanning and extensive neuropsychological testing. They will be tested on ERP paradigms designed to elicit the P300 (i.e. an auditory target detection task) and N400 (i.e. category and antonymic decision tasks) potentials. Twenty-one channels of EEG data will be collected and undergo ERP analysis, defining the P300 and N400 amplitudes and latencies by standard protocol. To test our main hypotheses, intergroup differences of the P300 and N40O amplitudes will be tested by using split-plot ANOVAs (group x electrode site). These ERP amplitudes will each be modeled as a function of specific clinical, neuropsychological and MRI volumetric measures using correlational and multiple regression analyses. Long-term Objectives: If this proposal were funded, it would allow the direct comparison of the P300 and N400 in an older cohort of schizophrenia patients. which is of great theoretical interest. This study would help define the clinical significance of specific ERP abnormalities with respect to symptomatology and type of cognitive deficit. It will further our understanding of late-onset schizophrenia. Future longitudinal studies would allow the etectrophysiologic quantification of cognitive decline and the testing of to what decree cognitive ERP abnormalities predict floor prognosis.

描述（改编自申请人摘要）：具体目的：检查 P300和N400事件相关电位（ERP）在一个良好的表征， 老年精神分裂症患者队列， 晚发精神分裂症（LOS）和早发精神分裂症患者 （EOS）。 P300和N400异常将分别与特定的 临床的神经心理学的 和神经解剖（ME容量测定）测量。 如果像我们假设的那样， EOS和LOS，这一胜利推进了我们对“ 精神分裂症”（即可能的异质性疾病）。 我们 初步数据表明LOS中P300振幅相对较少， 而N400等待时间在LOS中比在E05中稍微更延迟。 主要假设：I）EOS患者的P300振幅将降低， 与年龄匹配的正常对照组和LOS患者相比。 小型P300 振幅与注意力和学习障碍有关， 海马和丘脑体积更小。 2)N40O振幅降低将 主要发生在EOS患者中。 N400振幅将在 以更严重的阴性症状（尤其是贫困）为特征的患者 和异常的语言能力。 次级 假设包括：精神分裂症患者认知ERP异常 (P300或N400）的整体认知功能比 正常ER Pg. 方法：每组（EOS、LOS、对照组）将有三十名受试者 来自加州大学圣地亚哥分校老年精神病学临床研究中心， 年龄、教育程度、种族和性别相似。 所有受试者都将接受 最近接受了临床评估（7天内）、MRI扫描和 广泛的神经心理学测试 它们将在企业资源规划范例上接受测试 设计用于引出P300（即听觉目标检测任务）， N400（即类别和反义词决策任务）电位。 二十一 将收集EEG数据通道并进行ERP分析，定义 P300和N400振幅和潜伏期。 测试 我们的主要假设，P300和N40O振幅的组间差异 将使用裂图ANOVA（组x电极部位）进行检验。 这些 ERP振幅将各自被建模为特定临床， 神经心理学和MRI体积测量， 多元回归分析。 长期目标：如果该提案得到资助， 老年精神分裂症患者P300和N400的直接比较 患者 这在理论上很有意义。 这项研究将有助于 定义特定ERP异常的临床意义， 和认知缺陷的类型。 它将进一步促进我们的 对晚发性精神分裂症的理解 未来的纵向研究 将允许认知下降的电生理学量化， 认知ERP异常预测地板的实验研究 预后