Preventing alcohol misuse and consequences in vulnerable women

项目摘要 这个指导以患者为导向的研究职业发展奖（K23）将为Alyssa Norris博士提供 培训和研究活动需要成为一个独立的调查员，重点是 制定和评价针对年轻妇女酗酒问题的创新预防办法 使用，特别关注性少数群体。性少数女性表现出明显的 危险饮酒和酒精后果的风险增加。尽管有越来越多的证据表明， 酒精使用的差异，没有针对性少数群体妇女的经过检验的预防方法。这是 没有根据，因为性少数女性表现出独特的饮酒风险因素， 对目前治疗不满，以及为其他少数群体量身定制的文化节目 是有效的指导和培训团队包括以下领域的专家心理学家： 研究：对年轻妇女和弱势群体滥用酒精的简要干预（M。Carey; K. Carey）;指导干预开发的定性方法（古特里）; 指导干预内容的临床试验和潜在分析（Dunsiger）;性行为中的酒精滥用 少数民族妇女（刘易斯）。此外，我将继续担任精神病学和人类学助理教授， 行为（DPHB）在布朗大学和研究科学家在行为和预防中心 医学（CBPM）的Miriam医院。DPHB和CBPM致力于支持K获奖者， 完成其培训奖励活动，过渡到独立的NIH资助。目前，DHB 拥有超过200项正在进行的研究和5000万美元的外部赞助研究，并致力于支持 早期教师在他们的过渡到独立。诺里斯博士将运用通过拟议的 培训活动，以制定理论上合理和基于证据的预防方案， 减少性少数群体妇女滥用酒精。具体来说，诺里斯博士将开发一种预防 通过三个目标减少重度酒精使用的计划：（1）形成性需求评估：（1a）系统性 性少数女性饮酒的理论模型回顾，以及（1b）深入访谈（N = 20）， 通过参与式参与指导干预措施的制定;（2）完善治疗材料， 交付：（2a）二手数据分析，以确定对性少数群体妇女的有意义的规范反馈 （Kaysen）和（2b）认知访谈（N = 10），通过以下方式指导干预措施的制定： 参与式参与;（3）试点随机对照试验（N = 70），比较干预措施与 注意力匹配的控制组，以确定干预的可行性和可接受性， 第二个重点是初步的功效，以指导未来的赠款提案。

PROJECT ABSTRACT This Mentored Patient-Oriented Research Career Development Award (K23) will provide Dr. Alyssa Norris with the training and research activities needed to become an independent investigator focusing on the development and evaluation of innovative prevention approaches targeting young women’s alcohol use, with a specialized focus in sexual minority populations. Sexual minority women display markedly increased risk for hazardous alcohol use and alcohol consequences. Despite mounting evidence of these alcohol use disparities, there are no tested prevention approaches for sexual minority women. This is unwarranted given that sexual minority women evince unique risk factors for alcohol use and report dissatisfaction with current treatments, as well as that culturally-tailored programming for other minority groups is efficacious. The mentorship and training team includes expert psychologists in the following areas of research: brief interventions for alcohol misuse among young women and vulnerable populations (M. Carey; K. Carey); qualitative methodology to guide intervention development (Guthrie); longitudinal data analyses for clinical trials and latent analysis to guide intervention content (Dunsiger); and alcohol misuse among sexual minority women (Lewis). Further, I will continue to work as an Assistant Professor of Psychiatry and Human Behavior (DPHB) at Brown University and Research Scientist at the Centers for Behavioral and Preventive Medicine (CBPM) of The Miriam Hospital. DPHB and CBPM are dedicated to supporting K awardees from the completion of their training award activities to the transition into independent NIH funding. The DPHB currently has over 200 ongoing studies and $50 million in externally sponsored research and is dedicated to supporting early faculty in their transition to independence. Dr. Norris will apply the skills acquired through the proposed training activities to the development of theoretically-sound and evidence-based prevention programming to reduce alcohol misuse among sexual minority women. Specifically, Dr. Norris will develop a prevention program to reduce heavy alcohol use through three aims: (1) Formative needs assessment: (1a) systematic review of theoretical models of sexual minority women’s alcohol use, and (1b) in-depth interviews (N = 20) to guide intervention development through participatory engagement; (2) Refinement of treatment materials and delivery: (2a) secondary data analyses to determine meaningful normative feedback for sexual minority women (Kaysen), and (2b) cognitive interviews (N = 10) to guide the development of the intervention through participatory engagement; (3) Pilot randomized controlled trial (N = 70) comparing the intervention to an attention-matched control group to determine the feasibility and acceptability of the intervention, with a secondary focus on preliminary efficacy to guide future grant proposals.