Mentoring Biomechanics Research in Osteoarthritis

项目总结/摘要 这是一 重新提交 获得以患者为导向的研究（K24）的中期职业研究者奖。申请人， 博士Richard Souza是一名临床科学家，物理治疗和康复科学副教授 和加州大学旧金山分校弗朗西斯科。在他的职业生涯中，Souza博士建立在他的临床 背景通过详细和全面的研究对膝关节的负荷力学的影响， 髋关节骨关节炎（OA）。这些研究使用了生物力学方法，如动作捕捉系统， 通过测力法进行力量评估，并使用 先进的定量MRI指标，包括膝关节和髋关节软骨的T1ρ和T2弛豫时间映射， 半定量病变评分。结合他在肌肉骨骼生物力学方面的背景- 作为加州大学旧金山分校放射学和生物医学成像系的著名研究团队，Souza博士 能够发现关键的生物力学变量，有助于在OA过程中的最早的变化。 这些努力导致了最近完成的关于膝关节OA关节接触力学的R 01，以及 最近资助了MPI R 01用于髋关节OA进展。了解下肢的预测能力 关节生物力学来识别疾病进展一直是Souza博士工作的驱动力。 此外，Souza博士目前是一项研究的合作研究者，该研究评估了体重变化对 膝关节OA进展（PI：Link），最近还完成了研究翻译中心的资助 (MPIs Majumdar & Lane），为髋关节OA的R 01资助项目提供了关键的初步数据 进展这些活动和项目已经导致了一个广泛的多学科团队，专注于推进我们的 在以患者为导向的研究中理解OA。 当前应用程序请求资金（50%工资 支持）5年，以支持开展拟议的患者导向研究所需的受保护时间 并扩大UCSF社区内的辅导机会。 这一保护期将使博士。 苏扎继续领导一个富有成效的研究小组，并保持最低限度的教学和行政 在部门和大学层面的责任。Souza博士还将获得以下方面的额外培训： 先进的MR和PET MR分析，并能够参与临床研究培训（TICR） 程序.有很多机会来扩大苏扎博士已经开始的工作， 在临床研究的这个重要领域取得临床突破的潜力。

PROJECT SUMMARY/ ABSTRACT This is a resubmission for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Richard Souza, is a clinician-scientist, Associate Professor in Physical Therapy and Rehabilitation Science and the University of California, San Francisco. Throughout his career, Dr. Souza has built upon his clinical background through detailed and comprehensive studies on the influence of loading mechanics on knee and hip osteoarthritis (OA). These studies have used biomechanical methods such as motion capture systems, and strength assessment through dynamometry, and have characterized disease status and progression using advanced quantitative MRI metrics including T1ρ and T2 relaxation time mapping of knee and hip cartilage and semi-quantitative lesion scoring. Combining his background in musculoskeletal biomechanics with the world- renowned research team in the Department of Radiology and Biomedical Imaging at UCSF, Dr. Souza has been able to uncover key biomechanical variables that contribute to the earliest changes in the OA process. These efforts have resulted in a recently completed R01 on Joint Contact Mechanics in Knee OA, and a recently funded MPI R01 on hip OA progression. Understanding the predictive capability of lower extremity joint biomechanics to identify disease progression has been the driving force of Dr. Souza’s work. Furthermore, Dr. Souza is currently a Co-Investigator on a study evaluating the influence of weight changes on knee OA progression (PI: Link), and has also recently completed a Center of Research Translation grant (MPIs: Majumdar & Lane) that provided the key preliminary data for the funded R01 project of hip OA progression. These activities and projects have led to a broad multidisciplinary team focused on advancing our understanding of OA in patient oriented research. The current application requests funding (50% salary support) for 5 years to support the protected time necessary to conduct the proposed patient oriented research and to expand opportunities for mentoring within the UCSF community. This protected time will allow Dr. Souza to continue to lead a productive research group and maintain minimal teaching and administrative responsibility at the Departmental and University levels. Dr. Souza will also obtain additional training in advanced MR and PET MR analysis and enable participation in the Training in Clinical Research (TICR) program. There are plentiful opportunities to expand the work Dr. Souza has begun, and extremely high potential for clinical break-through in this important area of clinical research.