High School Student NeuroResearch Program (HSNRP)

亚利桑那大学的高中学生神经研究（NR）计划（HSNRP）培养，训练和维持 在不断增长的多样化，连接的劳动力管道和教师同行/近同行支持网络的探究精神。来 未来5年，HSNRP将每年提供10个有才华的，积极的亚利桑那州高中（8周）和3个进步 本科生（10周）全职密切指导动手，在基本，翻译，临床和流行的大脑- 研究经验强调正常和异常大脑的工作和紊乱（“最喜欢的器官”）。 脊髓和周围神经系统，并鼓励继续参与更先进的 研究导致科学/医学/健康相关的职业。HSNRP利用强大的基础设施，有效的招聘- 招聘/保留策略，吸引学生/教师/近同行的关系，以及我们出色的实习生生产力 长期由联邦政府资助的多学科弱势高中/本科生/医科学生暑期 研究计划和全年丰富。HSNRP学员将通过互动，融入一个创新的， 国际公认的基于问题的医学无知暑期研究所（SIMI）， 软件平台设计用于协作和交织生物医学已知和未知-我们知道我们 不知道（研究），不知道我们不知道（发现），认为我们知道但不知道（错误），即，未回答/ 无问的问题和无问的答案。夏季课程汇集了多层次的学员，其特点是 非正式的三周一般和NR生物医学专题研讨会和教师/SIMI校友“生活故事”与定期 全年的丰富活动强调“翻译翻译和科学提问”，并介绍 病理生物学、神经解剖学/生理学/药理学的语言和原理;临床相关性、实验室/ 领导力/多媒体沟通技能实践、社交网络和持续的职业咨询。在多个 基础和临床部门和专业的卓越中心，并由一个充满活力的经验丰富的多， 学科HSNRP领导团队，研究包括交叉主题和体内，体外，原位，计算机模拟， 神经生物学/疾病的建模方法，包括帕金森病和阿尔茨海默病，癫痫，创伤性 脑损伤、脑积水、肌营养不良、头痛、疼痛/成瘾、睡眠障碍、脑肿瘤、深部 脑刺激、分子精神病学、认知、血脑屏障/神经保护、神经影像学、神经基因组学/ 蛋白质组学、神经工程学、脑血液/淋巴血管动力学、中风和健康差异。基于我们 ~35年的跟踪记录和获得大量不同的弱势群体/URM亚利桑那州的学生反映在787 SIMI- 受过训练的高中生（包括110名HSNRP校友）跟踪到目前为止， 对于科学，特别是NINDS任务相关的基础科学/临床/教学职业，我们希望HSNRP 继续扩展和扩大NR多样性管道，并通过社区参与提高神经健康素养- 我是说。正在进行的评估包括反馈调查、数据库登记、好奇心量表、短期/长期随访，以及 个人档案记录了效率和培训模式的可持续性，并促进多样性和网络化。

University of Arizona's High School Student NeuroResearch (NR) Program (HSNRP) nurtures, trains, and sustains the spirit of inquiry in a growing diverse, connected workforce pipeline and faculty peer/near peer support network. Over the next 5 years, HSNRP will offer annually 10 talented, motivated Arizonawide high school (8 weeks) and 3 progressing undergraduate students (10 weeks) full-time closely mentored hands on-brain on basic, translational, clinical and popula- tion research experiences emphasizing the workings and disorders of the normal and abnormal brain (“favorite organ” of interviewees), spinal cord, and peripheral nervous system and encourage continuing involvement in more advanced research leading to science/medical/health-related careers. HSNRP leverages the strong infrastructure, effective recruit- ment/retention strategies, engaging student/faculty/near peer relationships, and outstanding trainee productivity of our long-standing federally funded multidisciplinary disadvantaged high school/undergraduate/medical student summer research programs and year-round enrichment. Interacting together, HSNRP trainees will be integrated into an innovative, internationally recognized question-based Summer Institute on Medical Ignorance (SIMI) with novel mobile-accessible software platforms designed for collaboration and interweaving biomedical Knowns and Unknowns – what we know we don't know (research), don't know we don't know (discovery), and think we know but don't (error), i.e., unanswered/ unasked questions and unquestioned answers. Bringing together multilevel trainees, the summer curriculum features informal triweekly general and NR biomedical topical seminars and faculty/SIMI alumni "life stories" with periodic enrichment activities year-round emphasizing "translating translation and scientific questioning," and introducing the language and principles of pathobiology, neuro-anatomy/physiology/pharmacology; clinical correlations, laboratory/ leadership/multimedia communication skill practice, social networking, and sustained career advising. Within multiple basic and clinical departments and specialized Centers of Excellence and overseen by an energetic experienced multi- disciplinary HSNRP leadership team, research encompasses cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to neurobiology/disorders ranging from Parkinson and Alzheimer disease, epilepsy, traumatic brain injury, hydrocephalus, muscular dystrophies, headache, pain/addiction, to sleep disturbances, brain tumors, deep brain stimulation, molecular psychiatry, cognition, blood-brain barrier/neuroprotection, neuroimaging, neurogenomics/ proteomics, neuroengineering, cerebral hemo/lymphovascular dynamics, stroke, and health disparities. Based on our ~35-year track record and access to large diverse pools of disadvantaged/URM Arizona students reflected in 787 SIMI- trained high school students (including110 HSNRP alums) followed to date with substantial numbers in or working toward science and specifically NINDS mission-related basic science/clinical/teaching careers, we expect HSNRP to continue to extend and enlarge the NR diversity pipeline and improve neurohealth literacy through community engage- ment. Ongoing evaluation includes feedback surveys, database registry, curiosity scales, short-/long-term followup, and individual portfolios to document efficacy and the training model's sustainability and promote diversity and networking.