HD2A Research Adoption Support Center (RASC)

总体：项目总结/摘要 作为对美国国立卫生研究院RFA-DA-22-050的响应，我们在此提出了一个HEAL Data 2Action 研究采用支持中心（RASC）。RASC的主要目的是阻止药物过量的浪潮 通过领导一项科学驱动的支持奋进，旨在有效地转化证据， 药物使用障碍和疼痛的干预措施。目前，药物过量死亡率上升。传播 D&I科学是科学和公共卫生差距的方法桥梁。 然而，D&I科学在应对阿片类药物流行病方面没有得到充分研究和利用。的象征 为了提高对D&I科学潜力的认识，将启动HEAL D2 A计划。程序 拥有10-12个创新项目，除了RASC，还有两个额外的中心：建模和 经济资源中心和数据基础设施支持中心。RASC将优化和提升 整个HD 2A计划的D&I能力。在这个整体组件中，我们记录了RASC是如何 组织成四个协同和动态的核心：行政、物质使用执行支助 核心、Pain实施支持核心和研究与评估核心。三大具体目标 在整个RASC中按策略排序，其所有核心如下： D&I研究能力的创新项目，并制定基于证据的 以及药物使用障碍和疼痛的新兴干预措施;协助创新项目如何 通过按需提供技术援助和采用创新的 实施支持计划，并制定SUD和疼痛干预D&I资源指南;最后， 推进HD 2A创新项目，以实现更大的可扩展性和可持续性潜力。RASC是 由4名在药物使用领域具有D&I研究和实践记录的MPI领导， 疼痛干预：McGovern（斯坦福大学），S. Becker（Brown），W.贝克尔（耶鲁）和布朗（西北）。的 MPI由互补的专家核心共同董事加入，并汇集了一个无与伦比的名册， 这些领域的高素质领导者-精心挑选，组织，并准备提供必要的 在整个HD 2A计划中提供实施支持。本RASC符合所有规定要求， 在RFA中列出。这个RASC的与众不同之处在于我们大胆的雄心，不仅要提高D&I能力， HEAL HD 2A计划的一部分，但影响远远超出HD 2A计划的范围。我们打算 提升药物使用和疼痛干预研究的D&I范式，从而确保无处不在 以及最需要的人民和社区公平地获得经过验证的干预措施。

OVERALL: PROJECT SUMMARY/ABSTRACT In response to the National Institutes of Health RFA-DA-22-050, we herein propose a HEAL Data2Action Research Adoption Support Center (RASC). The main purpose of the RASC is to stem the tide of overdose death in the US by leading a scientifically-driven support endeavor designed to effectively translate evidence- based interventions for substance use disorders and pain. Presently, overdose death escalates. Dissemination and implementation (D&I) science is the methodological bridge to both the scientific and public health gaps. Yet D&I science is understudied and underutilized in response to the opioid epidemic. Emblematic of heightened awareness for D&I scientific potential, the HEAL D2A Program will be launched. The program features 10-12 Innovation Projects, and, in addition to the RASC, two additional centers: Modeling and Economic Resource Center and Data Infrastructure Support Center. The RASC will optimize and elevate the D&I capability of the overall HD2A program. In this OVERALL component, we document how the RASC is organized into four synergistic and dynamic cores: Administrative, Substance Use Implementation Support Core, Pain Implementation Support Core, and a Research & Evaluation Core. Three overarching specific aims are strategically ordered across the RASC and all its cores follows: To ASSESS the current state of the HD2A Innovation Projects on D&I research capability, and develop an empirically-based catalog of evidence-based and emerging interventions for substance use disorders and pain; to ASSIST on how Innovation Projects can improve D&I methods and measures through on demand technical assistance and the use of an innovative Implementation Support Plan, and to develop SUD and Pain Intervention D&I Resource Guides; and lastly, to ADVANCE the HD2A Innovation Projects toward greater potential for scalability and sustainment. The RASC is led by 4 MPIs with demonstrated track records of D&I research and practice in the fields of substance use and pain interventions: McGovern (Stanford), S. Becker (Brown), W. Becker (Yale) and Brown (Northwestern). The MPIs are joined by complementary expert core co-directors, and have assembled an unmatched roster of highly-qualified leaders in these fields—carefully selected, organized and ready to provide the necessary implementation support across the HD2A program. This RASC meets all the specified requirements as outlined in the RFA. What distinguishes this RASC is our bold ambition to enhance not only the D&I capability of the HEAL HD2A program, but to influence the field far beyond the confines of the HD2A initiative. We intend to elevate the D&I paradigm of substance use and pain intervention research, and thereby ensure ubiquitous and equitable access to proven interventions by the people and communities who need them the most.