Neurobiology of pain experiences in youth in the ABCD study

ABCD研究中青少年疼痛经历的神经生物学 项目摘要 慢性疼痛是一个巨大的公共卫生问题，对心理健康具有广泛的影响和深刻的有害影响。 和身体健康，造成巨大的社会成本。在慢性疼痛综合征中， 在女性中更为普遍，在青春期发病率急剧增加。儿科慢性疼痛是 它本身就很昂贵，不幸的是，在青春期患有慢性疼痛的人很可能会有疼痛。 持续到成年，并经历高比例的共病抑郁症和药物滥用。有 慢性疼痛的已知风险因素，包括女性、低水平的体力活动、抑郁情绪，以及 睡眠障碍，但疼痛持续性的机制还没有很好地理解，特别是从一个 神经生物学观点此外，在儿科人群中，关于神经生物学的研究很少。 在足够大的样本中疼痛的相关性，以及对疼痛轨迹的有限前瞻性研究 整合了神经生物学数据在这项研究中，我们将前瞻性地检查神经生物学和 与青春期疼痛相关的生物心理社会特征，青春期是发展的关键时期， 情绪和调节功能，以预测随着时间的推移疼痛维持和相关影响。做 为此，我们将利用来自估计n=3773名11-12奥尔兹（49%为女性）参与ABCD的数据 在过去的一个月里报告经历过疼痛的研究，以及一个同等大小的比较样本， 根据年龄和人口统计学变量，他们在过去一个月内没有经历过疼痛。我们将利用休息 状态、功能和结构神经成像，以及风险因素的综合表型评估， 基线来表征这个大样本中疼痛经历的神经生物学相关性。然后我们将 检查随时间推移的疼痛轨迹（疼痛强度、疼痛强度、疼痛强度和疼痛强度报告的维持、增加或减少） 位置和疼痛相关的活动限制），并利用假设驱动的纵向建模方法 以确定基于大脑和生物心理社会的风险因素，预测持续和升级的疼痛。结果将 告知我们对发展的神经生物学和相关生物心理社会风险的基本理解 慢性疼痛在一个关键的发展时期，并将告知筛查方案的发展， 有针对性的预防措施。

Neurobiology of pain experiences in youth in the ABCD study Project Summary Chronic pain is a massive public health problem, with wide impact and profound detrimental effects on mental and physical health of those afflicted, resulting in large societal cost. Of chronic pain syndromes, many are more prevalent in females, and incidence increases dramatically during adolescence. Pediatric chronic pain is costly in its own right, and unfortunately individuals with chronic pain in adolescence are likely to have pain persist into adulthood, and experience high rates of comorbid depression and substance abuse. There are known risk factors for chronic pain, including female sex, low levels of physical activity, depressed mood, and sleep disturbance, but mechanisms underlying pain persistence are not well understood, particularly from a neurobiological perspective. Additionally, in pediatric populations there is minimal research on neurobiological correlates of pain in sufficiently large samples, and limited prospective research on pain trajectories incorporating neurobiological data. In this study, we will prospectively examine neurobiological and biopsychosocial features associated with pain during adolescence, a critical period for development of emotional and regulatory functioning, to predict pain maintenance and associated impacts over time. To do this, we will utilize data from an estimated n=3773 11-12 year olds (49% female) participating in the ABCD Study who report experiencing pain in the past month, as well as an equal-sized comparison sample, matched on age and demographic variables, who report experiencing no pain in the past month. We will utilize resting state, functional, and structural neuroimaging, and comprehensive phenotypic assessment of risk factors at baseline to characterize the neurobiological correlates of pain experiences in this large sample. We will then examine pain trajectories over time (maintenance, increases, or decreases in reports of pain intensity, pain locations, and pain-related activity limitations), and utilize hypothesis-driven longitudinal modeling approaches to identify brain-based and biopsychosocial risk factors predicting sustained and escalating pain. Results will inform our fundamental understanding of neurobiological and related biopsychosocial risk for the development of chronic pain during a key developmental period, and will inform development of screening protocols and targeted preventive interventions.