Adolescents at risk for chronic pain

青少年面临慢性疼痛的风险

• 批准号: 8301731
• 负责人: Anna Camille Wilson
• 金额: $ 11.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-20 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8301731
• 关键词: Abdominal Pain; Address; Adolescence; Adolescent; Adult; Anesthesiology; Anxiety; Applications Grants; Arthritis; Attention; Award; Back Pain; Behavior; Caregivers; Child; Childhood; Clinical; Clinical Research; Coping Skills; Data; Development; Development Plans; Environment; Environmental Risk Factor; Faculty; Family; Family history of; Female; Future; Gender Role; Genetic; Goals; Grant; Headache; Health; Health Promotion; Health Sciences; Healthcare; Impairment; Individual; Institution; Knowledge; Laboratories; Lead; Life; Longevity; Longitudinal Studies; Measurement; Medicine; Mental Depression; Mental Health; Mentors; Methodology; Methods; Migraine; Modeling; Oregon; Outcome; Pain; Pain Measurement; Pain Research; Pain Threshold; Pain intensity; Parenting behavior; Parents; Perioperative; Physical Function; Physical activity; Physiological; Play; Population; Populations at Risk; Preparation; Prevention; Preventive Intervention; Prospective Studies; Public Health; Quality of life; Recurrent pain; Reporting; Research; Research Ethics; Research Institute; Research Personnel; Research Support; Research Training; Resources; Risk; Risk Factors; Role; Sex Characteristics; Statistical Methods; Stimulus; Symptoms; Techniques; Testing; Time; Training; Training Programs; Translational Research; Twin Studies; Universities; Work; Writing; Youth; base; boys; career; career development; chronic pain; cohort; critical developmental period; design; disability; distraction; early adolescence; economic cost; experience; follow-up; functional disability; girls; innovation; intervention program; male; pain behavior; patient oriented; prevent; professor; prospective; protective behavior; psychologic; public health relevance; research and development; resilience; response; sex; skills; therapy design

DESCRIPTION (provided by applicant): The K23 candidate is an assistant professor in the Department of Anesthesiology and Perioperative Medicine at Oregon Health & Science University (OHSU). This award is expected to help transition the focus of the candidate's research and to provide additional training in risk for chronic pain in children and adolescents. The candidate's career goals are to develop an independent research career related to identification and prevention of chronic pain in at risk youth. Specific objectives of the career development and research training plan are to obtain the necessary training to evaluate individual and family predictors of pain and somatic symptoms among at-risk youth, and to use laboratory pain reactivity data to test hypotheses about risk and resilience factors related to the development of chronic pain in children over time. The candidate proposes a five-year training program with faculty mentors from a strong anesthesiology department. Her sponsor is a very experienced pediatric pain researcher whose work has focused on understanding and treating the functional consequences of chronic pain in children. Additional mentors are experts in laboratory pain methods, health promotion and prevention in at risk youth, and longitudinal studies with children. OHSU is an ideal institution for this award owing to the breadth of resources available (e.g., Oregon Clinical and Translational Research Institute training opportunities). In addition to intensive mentoring by nationally renowned patient-oriented researchers, the career development plan includes coursework and didactic training in chronic pain treatment, laboratory pain methodology, grant writing skills, and research ethics. Other activities in the plan include research training in statistical methods and supervised experience in preparation of grant proposals for independent research support. The candidate's proposed research involves three specific aims. The first aim is to examine individual and parental correlates of pain and somatic symptoms, physical functioning, and psychological functioning within two groups: 1) children of adult caregivers with chronic pain, and 2) children of healthy parents without chronic pain. The second aim is to follow this cohort of children over a one-year period in adolescence to identify risk and protective factors that predict pain and somatic symptoms longitudinally and examine the role of child sex. Parental, psychological, and health-related risk factors will be examined. The third aim is to compare parental responses during laboratory pain tasks in the two groups to better understand the influence of parent behaviors on children's pain experiences. This innovative study utilizes clinical and laboratory pain assessment techniques to provide new information about an at risk population, and will inform the development of preventive interventions. The combined skill set and experience gained from the candidate's career development and research plan will provide the necessary early career support for the candidate to establish a successful independent research career focused on prevention and treatment of chronic pain and related disability among youth at risk for chronic pain. Public Health Relevance: Family history of chronic pain increases the risk for the development of chronic pain in children and adolescents. This study will identify risk and protective factors associated with pain reactivity and somatic symptoms in children who are living with an adult caregiver with chronic pain. The long-term goal is to prevent the development of adult chronic pain and related disability.

描述（由申请人提供）：K23候选人是俄勒冈州健康与科学大学（OHSU）麻醉学和围手术期医学系的助理教授。该奖项预计将有助于转变候选人的研究重点，并提供儿童和青少年慢性疼痛风险的额外培训。候选人的职业目标是发展一个独立的研究生涯，与识别和预防高危青年的慢性疼痛有关。职业发展和研究培训计划的具体目标是获得必要的培训，以评估风险青年中疼痛和躯体症状的个人和家庭预测因素，并使用实验室疼痛反应数据来测试与儿童慢性疼痛发展相关的风险和弹性因素的假设。候选人提出了一个为期五年的培训计划与教师导师从一个强大的麻醉科。她的赞助商是一位经验丰富的儿科疼痛研究人员，其工作重点是了解和治疗儿童慢性疼痛的功能后果。其他导师是实验室疼痛方法，健康促进和预防高危青年以及儿童纵向研究方面的专家。OHSU是这个奖项的理想机构，因为它拥有广泛的资源（例如，俄勒冈州临床和转化研究所培训机会）。除了由全国知名的以患者为导向的研究人员进行密集的指导外，职业发展计划还包括慢性疼痛治疗，实验室疼痛方法，赠款写作技巧和研究道德方面的课程和教学培训。计划中的其他活动包括统计方法的研究培训和在编写独立研究支助赠款提案方面的监督经验。候选人提出的研究涉及三个具体目标。第一个目的是检查两组中疼痛和躯体症状，身体功能和心理功能的个体和父母相关性：1）患有慢性疼痛的成年照顾者的儿童，和2）没有慢性疼痛的健康父母的儿童。第二个目的是跟踪这一队列的儿童在青春期超过一年的时间，以确定风险和保护因素，预测疼痛和躯体症状纵向和检查儿童性别的作用。将检查父母，心理和健康相关的风险因素。第三个目的是比较两组儿童在实验室疼痛任务中父母的反应，以更好地了解父母行为对儿童疼痛体验的影响。这项创新的研究利用临床和实验室疼痛评估技术提供有关高危人群的新信息，并将为预防干预措施的制定提供信息。从候选人的职业发展和研究计划中获得的综合技能和经验将为候选人提供必要的早期职业支持，以建立一个成功的独立研究职业生涯，重点是预防和治疗慢性疼痛和有慢性疼痛风险的青年中的相关残疾。 公共卫生相关性：慢性疼痛家族史增加了儿童和青少年慢性疼痛发展的风险。本研究将确定与慢性疼痛成人照顾者一起生活的儿童的疼痛反应性和躯体症状相关的风险和保护因素。长期目标是预防成人慢性疼痛和相关残疾的发展。