Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults (MESA As)

项目摘要 这项名为“多种族成人低水平砷暴露与心血管疾病”的家长补助金， (MESA砷）"，旨在调查美国成年人低水平砷（As）暴露对心血管的影响， 多种族/民族群体。动脉粥样硬化多种族研究（梅萨）是一项基于人群的研究， 来自美国6个城市的近7,000名参与者，在过去20年中获得了已知的健康结果。期间 测量尿砷物种的父母赠款，我们注意到，我们可以确定硒（Se） 在我们测量As物种的同一分析运行期间，在P30试点研究的支持下， 我们正在梅萨尿样的一个子集中验证这些物种。我们建议扩大这项试验计划， 母公司补助金的范围，以评估低水平硒暴露与 心血管疾病，通过增加新的数据硒物种在尿液中的父母补助金。硒是一种 然而，人体必需的元素的安全范围很窄，这意味着低摄入量和高摄入量都会增加疾病风险。 人类主要通过尿排泄硒，尿硒形态是理解硒的特别兴趣 人体生物代谢和硒相关的健康结果。人尿硒形态可受 膳食硒摄入量和遗传变异性，并主导硒糖，三甲基硒离子， 无机硒氧阴离子。然而，硒对人体健康和疾病的个体影响仍然存在 由于很少进行流行病学研究来测量尿中的硒种类，因此在很大程度上未进行探索。我们计划 增加我们目前在梅萨的分析方法，最初建立的尿液中砷的形态，为 在一次测量中同时测定As和Se物种。硒形态的有效性 尿将提供关键数据，以检查个别硒物种和基因硒物种的关联 相互作用，而不是总硒，对人类健康的结果。

PROJECT SUMMARY The parent grant, entitled “Low-level Arsenic Exposure and Cardiovascular Disease in Multi-Ethnic Adults (MESA As)”, aims to investigate the cardiovascular effects of low-level arsenic (As) exposure in US adults of multiple racial/ethnic groups. The Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of nearly 7,000 participants from 6 US cities, with known health outcomes over two decades. During the measurement of urinary As species in the parent grant, we noticed that we could identify selenium (Se) species during the same analytical run in which we measured As species. With support from a P30 pilot study, we are validating those species in a subset of MESA urine samples. We propose to expand this pilot, and the scope of the parent grant, to assess the extent to which low-level Se exposure is associated with cardiovascular disease, by adding new data on Se species in urine to the parent grant. Selenium is an essential element with a narrow safety range, meaning that both low and high intake can increase disease risk. Humans mainly excrete Se through urine and urinary Se speciation is of particular interest for understanding human bio-metabolism and Se-related health outcomes. Human urinary Se speciation can be influenced by dietary Se intake and genetic variability and is dominated by selenosugars, trimethylselenonium ion, and inorganic Se oxyanions. However, the individual influence of Se species on human health and disease remains largely unexplored as it is rare for epidemiological studies to measure Se species in the urine. We plan to augment our current analytical method in MESA, originally established for speciation of As in urine, for the simultaneous determination of As and Se species in a single measurement. The availability of Se species in urine will provide key data to examine the association of individual Se species and gene-Se species interactions, rather than total Se only, on human health outcomes.