TeleLine: Plug-n-Play Inline Respiratory Remote Data Acquisition System

项目摘要 五分之一的美国人生活在由农村医院提供服务的农村社区，但只有1%的ICU资源是 提供给这些医院。当患者所需的护理水平超出了医院的能力时， 入院后，病人会被转往设备较佳的三级医院。大约有80万 在美国（COVID前），每年都有患者需要机械通气。机械处理 机械通气患者不仅需要专门的设备，而且还需要专门的技能，这是困难的， 在农村地区找到。我们的小组提出了新的研究，以证明远程医疗在世界范围内的力量。 通过扩大肺部重症监护专家的覆盖范围，通过启用肺部重症监护 在偏远地区的专家，农村医院可以治疗更多的病人，而无需转移他们。数据表明 从乡村医院转到三级护理中心的患者遭受护理延迟，不良事件， 和更高的死亡率不幸的是，由于高传输速率，大量的收入损失， 农村医院的业务预算一般不足以支持更换和整合 尖端的医疗设备来获得远程医疗能力。我们的研发重点是 准备一种解决方案，可以扩大地理范围，增强肺功能的远程能力， 通常位于城市和郊区的护理专家， 同时保护医院在呼吸机设备上的传统投资。为了实现这些目标，我们 开发了一种在线呼吸回路传感器（TeleLine）原型，我们将进一步完善， 商业化和最终的实地部署。TeleLine是一种非侵入式传感套件， 现有的制冷机，并配备数据记录和远程监控能力。患者的 可以在本地捕获对机械通气的呼吸反应，并安全地传输到远程 在肺部重症监护方面具有适当专业知识的研究中心。我们将进一步发展电话线在两个目标： 1)改进现有的TeleLine原型，用于即插即用、供应商不可知的呼吸机接口，以及 呼吸机数据记录;目标2）开发和基准支持数据收集和机器学习 基础设施，以促进远程病人护理。该项目的成功完成将使第二阶段 增强器械可制造性的计划，清除初始器械监管的关键基准 批准，并进一步开发TeleLine系统的机器学习辅助功能。

Project Summary One in five Americans live in a rural community served by rural hospitals yet only 1% of ICU resources are available to these hospitals. When the level of care required by a patient exceeds the capabilities of the admitting hospital, the patient is transferred to a better-equipped tertiary hospital. Approximately 800,000 patients require mechanical ventilation every year in the United States (pre-COVID). Treating mechanically ventilated patients not only requires specialized equipment, but also specialized skills as well which are difficult to find in rural settings. Our group proposes novel research to demonstrate the power of telemedicine in the rural setting by extending the reach of pulmonary critical care specialists. By enabling pulmonary critical care specialists at distant sites, rural hospitals can treat more patients without transferring them. Data suggests patients who are transferred from rural hospitals to tertiary care centers suffer delays in care, adverse events, and higher mortality. Unfortunately, due to high transfer rates, significant amounts of revenue are lost and operating budgets at rural hospitals are generally inadequate to support replacement and integration of cutting-edge ventilators to gain telemedicine capabilities. Our research and development is focused on preparing a solution which can extend the geographic reach and enhanced remote capabilities of pulmonary care specialists who are typically located in urban and suburban settings to those rural institutions while at the same time protecting the hospital’s legacy investment in ventilator equipment. To achieve these goals, we have developed an in-line respiratory circuit sensor (TeleLine) prototype that we will further refine for commercialization and eventual in-field deployment. The TeleLine is a non-invasive sensing suite to any existing ventilators and equipping them with both data logging and remote monitoring capability. The patient’s respiratory response to mechanical ventilation can be captured locally and securely transmitted to a remote site with appropriate expertise in pulmonary critical care. We will further develop the TeleLine in two aims: Aim 1) to refine the existing TeleLine prototype for plug-and-play, vendor-agnostic ventilator interfacing, and ventilator data logging; and Aim 2) to develop and benchmark supporting data collection and machine learning infrastructure for facilitating remote patient care. Successful completion of this project will enable a Phase II program that enhances device manufacturability, clears critical benchmarking for initial device regulatory approval, and further develops machine-learning assistance capabilities of the TeleLine system.