The Intersection between Loss of Control Eating and Obesity: The Role of Restriction and Food Reinforcement.

项目总结/摘要 该提案是为凯瑟琳Balantekin博士颁发的指导研究科学家发展奖（K 01）， Rd.培训：我的长期职业目标是成为一名研究摄食行为的独立调查员， 儿童和青少年肥胖危险因素与共病超重/肥胖和饮食失调。的 拟议的K 01将通过在以下领域提供培训、经验和指导来帮助实现这一目标：1） 为超重/肥胖和饮食失调共病患者确定新的治疗靶点; 2） 应用基本的行为科学原理来理解摄食行为; 3）翻译研究结果 从实验室研究到干预措施; 4）评估行为表型如何影响肥胖风险， 时间这个K 01将为我提供受保护的时间来接受必要的培训，以提高我的 拥有这四个领域的专业知识，并将推动我成为一名专注于 肥胖和饮食失调的交叉点研究：儿童超重/肥胖是一个主要的公众 健康问题和超重/肥胖儿童在医疗和心理方面的风险增加 合并症饮食失调始于童年，通常表现为饮食失控， 特别是在超重/肥胖的儿童中。孩子吃得太多，或者感觉自己无法控制 一个人吃什么或吃多少，都会增加肥胖的风险。然而，对机制知之甚少 增加了这种风险。父母的限制和食物的相对强化值（RRV），或 获得食物的动机与儿童超重/肥胖独立相关， 这表明，这两个也可能与发展和/或维护的反。建议的K 01是 旨在探讨过度进食、父母限制暴露和食物RRV之间的关系 关于肥胖风险。总结：本研究的结果将有助于确定NIDDK的潜在靶点 R 03拨款申请，以试点肥胖预防试验对有饮食失调风险的儿童的有效性 治疗肥胖症这个K 01将为我提供识别行为表型的培训和专业知识， 治疗目标，应用基本的行为科学原理来理解摄食行为， 翻译科学，并获得有关新的统计方法来分析纵向 数据和摄食行为数据。在这个奖项结束时，我将成为一名独立的研究科学家， 在肥胖和饮食失调的交叉点上的摄食行为。

PROJECT SUMMARY/ABSTRACT This proposal is for a Mentored Research Scientist Development Award (K01) for Katherine Balantekin, PhD, RD. Training: My long-term career goal is to be an independent investigator studying ingestive behavior and obesity risk factors in children and adolescents with co-morbid overweight/obesity and disordered eating. The proposed K01 will help achieve this by providing training, experience, and mentorship in the areas of: 1) identification of novel treatment targets for those with comorbid overweight/obesity and disordered eating; 2) applying basic behavioral science principles towards understanding ingestive behavior; 3) translating findings from lab-based studies into interventions; 4) evaluating how behavioral phenotypes influence obesity risk over time. This K01 will provide me with the protected time to receive the necessary training to enhance my expertise in these four areas and will propel me to becoming an independent research scientist focused on the intersection of obesity and disordered eating. Research: Overweight/obesity among children is a major public health problem, and children with overweight/obesity are at increased risk for both medical and psychological co-morbidities. Disordered eating begins in childhood, and often manifests as loss of control (LOC) eating, especially in children with overweight/obesity. Children with LOC eating, or the feeling that one cannot control what or how much one is eating, are at increased risk for obesity. However, less is known about mechanisms that increase this risk. Both parental restriction and the relative reinforcing value (RRV) of food, or the motivation to obtain food, are independently associated with child overweight/obesity, and preliminary work suggests that both may also be related to the development and/or maintenance of LOC. The proposed K01 is designed to explore the relationships among LOC eating, exposure to parental restriction, and RRV of food with respect to obesity risk. Summary: Findings from this study will help identify potential targets for a NIDDK R03 grant application to pilot the efficacy of an obesity prevention trial for children with disordered eating at risk for obesity. This K01 will provide me with the training and expertise in identifying behavioral phenotypes for treatment targets, applying basic behavioral science principles towards understanding ingestive behavior, translational science, and acquiring knowledge about novel statistical approaches to analyzing longitudinal data and ingestive behavior data. At the end of this award, I will be an independent research scientist studying ingestive behavior at the intersection of obesity and disordered eating.