2023 Preclinical Form and Formulation for Drug Discovery Gordon Research Conference and Gordon Research Seminar

摘要 全球健康、罕见疾病和其他未满足的医疗需求在配方预测方面具有独特的挑战， 材料表征，以及化学、生物和细胞药物的递送。2023年的目的 戈登研究会议和研讨会（GRC/GRS）的临床前形式和配方的药物发现 加速将有前途的候选药物转化为商业药物，方法是：（1）传播 与材料表征、配方和交付有关的最新科学和技术进展 化学、生物和细胞医学;（2）培养一个充满活力、包容性和多样性的科学网络;（3） 教育和吸引下一代科学家。该GRC/GRS汇集了专业知识， 未发表的关于不同治疗方法的数据，以突出形式和制剂的挑战和机遇， 跨越这些模式，并整合交叉技术和方法。这些疗法包括 双特异性和多功能小分子、肽、蛋白质、核酸和“活”微生物药物 具有从传染病到肿瘤学的广泛应用。配制和表征 这些技术包括新的实验方法和计算机模拟方法，其最终目标是发现 可以应用于许多药物以防止失败和无效的一般原则和工具。传播 新知识和技术的广泛使用和进一步发展， 将使更多的药物有效地进入临床。形式和配方还可以解决关键的全球性问题， 卫生挑战，这次会议将扩大世界卫生组织第4区稳定的必要性， 分布要求、低成本和易于施用的制剂和递送系统。这次会议 将分享成功，持续的困难，以及从学术，工业，政府和 非营利科学家，以满足世界各地患者的需求。除了分子和专业的多样性， 该计划议程和招募参与者的努力反映了领导团队对 包容性会议，与会者包括来自制药业代表不足的群体的科学家， 化学和工程学这种包容性的一个重要组成部分是培养下一代科学家 戈登研究会议，为所有职业阶段的科学家，和戈登 研究研讨会，研究生和博士后科学家，使早期的职业科学家从广泛的 一系列的背景，分享他们的研究，并与该领域的领导者亲自互动，以提高他们的 网络和培养他们的职业目标。

Abstract Global health, rare diseases, and other unmet medical needs have unique challenges in formulation prediction, materials characterization, and delivery of chemical, biological, and cellular medicines. The purpose of the 2023 Gordon Research Conference and Seminar (GRC/GRS) on Preclinical Form and Formulation for Drug Discovery is to accelerate the translation of promising drug candidates into commercial medicines by: (1) disseminating the latest scientific and technical advances relevant to materials characterization, formulation and delivery of chemical, biological, and cellular medicines; (2) fostering a vibrant, inclusive, and diverse scientific network; (3) educating and engaging the next generation of scientists. This GRC/GRS brings together expertise and unpublished data on diverse therapeutics to highlight the form and formulation challenges and opportunities that span these modalities and integrate cross-cutting techniques and approaches. These therapeutics include bispecific and multi-functional small molecules, peptides, proteins, nucleic acids, and “living” microbial medicines with broad applications ranging from infectious diseases to oncology. Formulation and characterization technologies cover both novel experimental and in silico approaches, with the ultimate goal of discovering general principles and tools that can be applied to many drugs to prevent failure and inefficiency. Dissemination and discussion of new knowledge and technologies are necessary to enable broad use and further progress that will translate more drugs efficiently into the clinic. Form and formulation can also enable solutions to critical global health challenges, and this meeting will amplify the need for World Health Organization zone 4 stability and distribution requirements, low cost, and easy to administer formulation and delivery systems. This conference will share successes, continuing difficulties, and lessons learned from academic, industrial, government, and non-profit scientists to meet the needs of patients across the world. Beyond molecular and professional diversity, the program agenda and efforts to recruit participants reflect the commitment of the leadership team to an inclusive meeting with diverse participants including scientists from groups underrepresented in pharmaceutics, chemistry and engineering. An important component of this inclusivity is training the next generation of scientists and the combination of the Gordon Research Conference, for scientists at all career stages, and the Gordon Research Seminar, for graduate student and postdoctoral scientists, enables early career scientists from a broad range of backgrounds to share their research and interact personally with leaders in the field to grow their networks and nurture their career goals.