2023 Muscle: Excitation-Contraction Coupling Gordon Research Conference and Gordon Research Seminar

摘要 这项建议寻求部分支持戈登研究会议（GRC）对肌肉兴奋- 收缩耦合（ECC）。这是关于这一重要议题的唯一重大国家/国际会议。为 心脏，骨骼和平滑肌，我们将深入研究正常的生理功能，疾病功能障碍， 从分子生物物理学、电和钙依赖性信号传导到 综合功能。这个GRC将于2023年6月4日至9日在新罕布什尔州的Colby-Sawyer学院举行。的 该计划是在与ECC研究领导人的广泛咨询小组协商后制定的。此组和 小组委员会由Donald M Bers博士（美国）和Ana Gómez博士（法国）担任主席。还寻求支持， 相关的戈登研究研讨会（GRS），由早期研究者（ESI; 学生、博士后和新教员）。该GRS紧接在GRC之前，由两名ESI主持 （新西兰的Michelle Munro和美国的弗朗西斯科阿尔瓦拉多）。联合国的两个首要目标 GRC和GRS将：1）聚集顶尖的科学家演讲者和参与者分享新的突破， 促进和参与深入和广泛的讨论，从分子机制到综合 心脏、骨骼肌和平滑肌的生理学和病理生理学，以及2）增加可见性， 初级ECC ESI的领导，并通过提供一个互动的非正式 论坛，介绍他们的工作和网络。2023年ECC GRC将有约37位演讲者，约6个简短的演讲 突出精选的海报摘要和~18个主题讨论领导者。科学会议将详细介绍 ECC的结构-功能在多个尺度上，从分子水平到转化为新的治疗方法 与ECC相关的策略。会议包括，1）L型钙通道，2）Ryanodine受体，3）IP 3受体 恶性高热和CPVT-心律失常，5）钙池操纵的钙内流，TRP 和牵张激活通道，6）肌营养不良和糖尿病，以及8）心力衰竭和骨骼肌 疲劳心脏，骨骼和平滑肌将一起讨论，以突出的相似性和差异 在健康和疾病的分子和肌肉水平上加强对每种肌肉类型的理解。档案处 将帮助ESI发展自信心和社区意识，鼓励他们充分参与 在GRC期间与高级同事进行正式和非正式讨论。GRC将重点介绍ESI演示文稿 在几个方面（简短的会谈，海报闪光灯会谈和讨论共同领导人），提高这些曝光率， 初级调查员和他们的新研究。我们预计将吸引约175名基础和临床研究人员 职业阶段、性别、种族、遗产、研究学科、机构和地理位置。我们的目标 促进：1）公开对话和交流，2）环境服务机构的知名度和职业发展，3）实质性 新的和深入的了解肌肉如何正常运作，在疾病中出了什么问题， 治疗策略可以使那些受多种疾病折磨的人受益。

ABSTRACT This proposal seeks partial support for the Gordon Research Conference (GRC) on Muscle Excitation- Contraction coupling (ECC). This is the only major national/international meeting on this important topic. For cardiac, skeletal and smooth muscle we will delve into normal physiological function, dysfunction in disease and potential therapeutics at levels from molecular biophysics, electrical and calcium-dependent signaling to integrated function. This GRC will meet June 4-9, 2023 at Colby-Sawyer College in New Hampshire. The program was developed in consultation with a broad advisory group of leaders in ECC research. This Group and the GRC are chaired by Drs. Donald M Bers (USA) and Ana Gómez (France). Support is also sought for an associated Gordon Research Seminar (GRS) that is led by and focused upon early stage investigators (ESIs; students, postdocs and new faculty). This GRS immediately precedes the GRC and is chaired by two ESIs (Michelle Munro in New Zealand, and Francisco Alvarado in the USA). The two overarching objectives of the GRC and GRS are to: 1) Assemble top-notch scientist-speakers and participants to share new breakthroughs, stimulate and participate in deep and broad discussions that span from molecular mechanisms to integrated physiology and pathophysiology in cardiac, skeletal and smooth muscle, and 2) Increase the visibility and leadership of junior ECC ESIs and inspire/motivate their research careers by providing an interactive informal forum in which to present their work and network. The 2023 ECC GRC will have ~37 speakers, ~6 shorter talks to highlight selected poster abstracts and ~18 topic discussion leaders. Scientific sessions will detail the structure-function of ECC at multiple scales ranging, from molecular level to the translation into new therapeutic strategies for ECC-related. Sessions include, 1) L-type Ca Channels, 2) Ryanodine Receptors, 3) IP3 Receptors and Nuclear Signaling, 4) Malignant Hyperthermia and CPVT-Arrhythmias, 5) Store-Operated Ca entry, TRP and stretch-activated channels, 6) Muscular Dystrophy and Diabetes, and 8) Heart Failure and Skeletal Muscle Fatigue. Cardiac, skeletal and smooth muscle will be discussed together to highlight similarities and differences to enhance understanding of each muscle type at molecular and muscle levels in health and disease. The GRS will help ESIs develop self-confidence and sense of community that will encourage their full engagement in formal and informal discussion with senior colleagues during the GRC. The GRC will highlight ESI presentations in several ways (short talks, Poster Flash talks and discussion co-leaders) that heighten the exposure of these junior investigators and their novel research. We expect to attract ~175 basic and clinical researchers across career stages, genders, races, heritages, research disciplines, institutions, and geographical locations. We aim to promote: 1) open dialogue and communication, 2) visibility and career development for ESIs, 3) substantial new and deep knowledge about how muscle functions normally, what goes wrong in disease and what novel therapeutic strategies may benefit those afflicted by numerous diseases.