2023 Stochastic Physics in Biology GRC & GRS

摘要/摘要 在最基本的层面上，热力学和质量作用等物理和化学定律支配着 活细胞的运作。然而，在功能水平上，生物分子何时、何地、以何种速度 通过其与伴侣的结合来执行其功能，或者其酶作用是随机的，并且只能是 用概率而不是确定性术语描述的。在这个层面上，实验和实验之间的整合 理论变得极其重要，因为需要发展新的理论来解释随机 实验观察和指导进一步的实验探索，需要进行实验 以检验理论预测并确立生物学意义。随机物理的重要性在 生物学已经得到了越来越多的研究界的认可，并在主要期刊上发表了论文。这个 2023年GRC随机物理学在生物学中的目标是在随机物理理论与生物学之间架起桥梁 通过将一群杰出而多样化的物理学家、数学家、工程师聚集在一起进行实验 以及走在研究前沿的生物学家。它将解决在理解复杂性方面新出现的挑战 利用随机物理学中的原理和理论研究生物系统的行为。一款精心设计的 会议计划包括九个科学会议、四个海报会议、一个动力小时和三个社交小时 为参与者营造一个激励的环境，并成为不断增长的 社区。这次会议将为NIBIB的使命提供肥沃的科学土壤 加快生物物理和生物医药技术在人类健康领域的应用。

Summary/Abstract At the most fundamental level, physical and chemical laws such as thermodynamics and mass action govern the operations of a living cell. At the functional level, however, when, where and at what rate a biomolecule executes its function through its binding to a partner or its enzymatic actions is stochastic, and can only be described in probabilistic instead of deterministic terms. At this level, the integration between experiments and theories becomes extremely important, because new theories need to be developed to explain stochastic experimental observations and guide further experimental explorations, and experiments need to be conducted to test theoretical predications and establish biological significance. The importance of stochastic physics in biology has been recognized by the growing research community and publications in premier journals. The 2023 GRC Stochastic Physics in Biology aims to bridge stochastic physical theories with biological experiments by bringing together an outstanding and diverse group of physicists, mathematicians, engineers and biologists at the forefront of research. It will address emerging challenges in understanding complex behaviors of biological systems using principles and theories in stochastic physics. A carefully designed conference plan with nine scientific sessions, four poster sessions, one Power Hour, and three social hours will foster a stimulating environment for participants and serve as a vigorous intellectual hub for the growing community. The conference will benefit the mission of NIBIB by providing a fertile scientific ground to accelerate the application of biophysical and biomedical technologies to human health.