Novel Insights into the Pathobiology of Alphavirus Infections

蚊子传播的病毒感染正在世界范围内以惊人的速度增加。罗斯河病毒在澳大利亚、巴布亚新几内亚和太平洋岛屿的部分地区流行，而基孔肯雅病毒在全球分布，并引起涉及数百万人的反复大流行。这些病毒在感染后的几个月内会引起严重的肌肉骨骼疾病。该项目旨在确定这些病毒如何与人类宿主相互作用导致疾病，并可能为新的治疗方法提供基础。

Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.