Ischemic Brain Damage and Single Quantum Sodium MRI

项目摘要 该建议旨在评估组织钠浓度（TSC）的作用，如通过磁共振成像测量的。 磁共振成像（MRI），对脑缺血的急性管理。为了实现这一目标，我们将 介入治疗的急性卒中患者在再通治疗后20分钟内进行MRI扫描 纽约大学医学院神经放射学服务。我们的基本假设 具有高于65mM的TSC的脑组织代表无活力的组织，因此， 任何类型的再灌注治疗。这一假设是从我们以前的工作中的观察中得到证实的。 非人灵长类动物可逆性大脑中动脉闭塞期间的系列MR成像。这一假设 将通过比较严重升高的TSC（高于65 mM）的空间共配准体积进行测试， 再通和每个研究受试者脑上的梗死体积（在30天随访时）。我们 计划在本五年计划期间共入组120例受试者，以考虑 疾病，同时仍达到所需的统计学显著性。

PROJECT SUMMARY This proposal seeks to evaluate the role of tissue sodium concentration (TSC), as measured by magnetic resonance imaging (MRI), on the acute management of brain ischemia. To achieve this goal, we will perform MRI scans within 20 minutes of recanalization therapy on acute stroke patients treated in the Interventional Neuroradiology service at the New York University School of Medicine (NYUSOM). Our underlying hypothesis is that brain tissue with a TSC above 65mM represents non-viable tissue and, therefore, will not recover upon reperfusion therapy of any type. This hypothesis was borne out from observations during our previous work on serial MR imaging during reversible middle cerebral artery occlusion of non-human primates. This hypothesis will be tested by comparing the spatially co-registered volume of critically elevated TSC (above 65mM) after recanalization and the volume of infarction (on the 30 day follow up) on the brain of each study subject. We plan to enroll a total of 120 subjects during this five-year proposal in order to account for the heterogeneity of the disease while still attaining the required statistical significance.