Biophysical muscle modeling software for enhancing open science

项目摘要 这个补充的目标是使一个大社区的肌肉骨骼建模研究人员很容易 访问并稳健地使用由母基金生成的经验证的生物物理肌肉模型， 肌肉功能的多尺度模拟。到目前为止，肌肉骨骼运动 模拟（<5）使用基于生物制药的肌肉模型;那些可用的并不容易 可推广以供其他研究人员使用。从父母补助金的研究建立了新的，实验性的- 生物物理肌肉模型的验证配方，以再现肌肉力量生成的新特征， 理解行为和临床背景下的感觉运动功能。我们使用MyoSim软件平台 由Co-I坎贝尔开发，以证明生物物理肌肉模型优于标准模型 运动的肌肉骨骼模拟中使用的现象学模型。然而，这将是困难的， 其他研究人员可以在其他运动环境中轻松实现这些模型。这一补充将使 更广泛地传播我们正在进行的和以前的研究，以加强开放科学和加速进展， 肌肉、心脏和肌肉骨骼建模领域的多尺度建模。软件 补充目标1将改进、标准化和记录MyoSim软件，以便可以轻松 与其他多尺度模拟集成在科学计算平台上，如MATLAB和Python。 软件补充目标2将整合MyoSim肌肉模型与OpenSim，一个NIH资助的 拥有约70，000名用户的肌肉骨骼模拟平台。该补充还将支持虚拟教程 针对肌肉建模研究人员的研讨会，包括肌肉和心脏研究人员，包括那些 使用有限元模型和OpenSim肌肉骨骼建模社区。创造开放， 用于多尺度建模的可通用和可扩展的MyoSim功能将促进科学创新 增强肌肉骨骼研究的开放科学，并大幅增加MyoSim用户群。

Project Summary The goal of this supplement is to enable a large community of musculoskeletal modeling researchers to easily access and robustly use validated biophysical muscle models generated by the parent grant to generate multiscale simulations of muscle function. To date, there are extremely few musculoskeletal movement simulations (<5) that use biophysically-based muscle models; those that are available are not easily generalizable for use by other researchers. Research from the parent grant establishes new, experimentally- validated formulations of biophysical muscle models to reproduce novel features of muscle force generation for understanding sensorimotor function in behavioral and clinical contexts. We use the MyoSim software platform developed by Co-I Campbell to demonstrate the superiority of biophysical muscle models over standard phenomenological models used in musculoskeletal simulations of movement. However, it will be difficult for other researchers to easily implement these models in other movement contexts. This supplement will enable broader dissemination of our ongoing and prior research, to enhance open science and accelerate progress in multiscale modeling in the muscle, cardiac, and musculoskeletal modeling communities. Software Supplement Aim 1 will improve, standardize, and document MyoSim software so that it can be easily integrated with other multiscale simulations on scientific computing platforms such as MATLAB and Python. Software Supplement Aim 2 will integrate MyoSim muscle models with OpenSim, an NIH-funded musculoskeletal simulation platform with ~70,000 users. The supplement will also support virtual tutorial workshops aimed at muscle modeling researchers including muscle and cardiac researchers, including those using finite element models, and the OpenSim musculoskeletal modeling community. Creating open, generalizable and extensible MyoSim functionality for multiscale modeling will increase scientific innovation and enhance open science in musculoskeletal research, and dramatically increase the MyoSim user base.