RespiDART 2022: Frontiers in Drug Development against Respiratory Viruses

摘要/项目摘要 自1995年以来，DART系列会议一直关注抗病毒治疗的最新进展， 病毒如HIV、B型肝炎和C型肝炎。就像病毒不断进化一样，DART系列努力 适应当今全球社会面临的新挑战。呼吸道病毒如RSV和 流感病毒长期以来一直威胁着人类健康，特别是婴儿等脆弱人群， 老年人和免疫力低下的人最近的新型冠状病毒大流行彻底震撼了世界， 它清醒地提醒我们在这个竞技场继续研究和发展的重要性。 通过汇集世界领导人和主要意见持有者，RespiDART 2022将应对毒品和犯罪问题的挑战。 发现/开发和针对呼吸道病毒的疫苗。具体目标是：1.提供一种 互动研讨会设置，临床医生，科学家和卫生保健工作者可以分享和讨论 呼吸道病毒治疗领域的最新医学和科学发展; 2.制定跨学科计划，促进科学知识的中立和平衡交流。 生物学、化学、药理学、临床研究和公共卫生领域的知识， 主题包括流行病学和治疗障碍，疫苗开发以及最近的临床进展， 小分子; 3.加强对青年科学家的培训，为他们提供更多的机会， 代表性不足的科学家和卫生保健工作者通过参加奖学金在CME认证 设置.教育目标是：1。呼吸道病毒的流行病学、筛查和诊断 特别关注SARS-CoV-2。2.药物发现和开发。3.新的临床评价 正在开发的针对呼吸道病毒如SARS-CoV-2的治疗剂。流感病毒RSV 副流感病毒和偏肺病毒。4.长期COVID-19。5.呼吸道病毒酶学，宿主病毒 相互作用和病毒复制。6.免疫学和疫苗开发。7. SARS-CoV-2变异体的影响 在治疗学、疫苗和流行病学上的出现。8.新测定和动物模型开发。9. 耐药性、疫苗耐药性和病毒进化。10. SARS-CoV-2和其他病毒感染， 成人和儿童呼吸道疾病，包括SARS-CoV-2/病毒合并感染。设计& 方法：RespiDART 2022将在墨西哥洛斯卡沃斯举行，为期两天，地点是 国内和国际代表都可以方便地访问。墨西哥医生（包括那些为 当地居民）以及来自不发达国家的众多科学家将应邀出席。的 课程将包括讲座、口头摘要报告、小组讨论和海报展示。虚拟 如果目前的流行病使前往会议不安全，将设立参加会议的选择。 我们认为，RespiDART 2022是一个非常需要和及时的平台，可以讨论最新的 在这个快速发展的全球卫生领域的发展。

Abstract/ Project Summary Since 1995, the DART conference series have focused on the latest developments in antiviral therapy against viruses such as HIV, hepatitis B and hepatitis C. Just as viruses are ever evolving, the DART series strives to adapt itself to emerging challenges facing today’s global community. Respiratory viruses such as RSV and influenza virus have longed threatened human health, especially in vulnerable populations such as infants, the elderly, and the immunocompromised. The recent coronavirus pandemic has shaken the world to its core and has served as a sobering reminder of the importance of continued research and development in this arena. By bringing together world leaders and key opinion holders, RespiDART 2022 will tackle challenges in drug discovery/development and vaccines against respiratory viruses. The specific aims are: 1. To provide an interactive workshop setting where clinicians, scientists and health care workers can share and discuss the latest medical and scientific developments in the field of therapeutics development against respiratory viruses; 2. Develop a cross-disciplinary program that facilitates the neutral and balanced exchange of scientific knowledge in the areas of biology, chemistry, pharmacology, clinical research and public health as related to topics such as epidemiology and barriers to treatment, vaccine development, and recent clinical advances of small molecules; 3. Enhance the training of young scientists and provide increased opportunities for underrepresented scientists and health care workers through attendee scholarships in a CME accredited setting. The educational objectives are: 1. Epidemiology, screening, and diagnosis of respiratory viruses with a special focus on SARS-CoV-2. 2. Drug discovery and development. 3. Clinical evaluation of novel therapeutics in development against respiratory viruses such as SARS-CoV-2. influenza virus, RSV, parainfluenza virus, and metapneumovirus. 4. Long COVID-19. 5. Respiratory virus enzymology, host-virus interactions and virus replication. 6. Immunology and vaccine development. 7. Impact of SARS-CoV-2 variant emergence on therapeutics, vaccines and epidemiology. 8. Novel assay and animal model development. 9. Drug resistance, vaccine resistance, and viral evolution. 10. SARS-CoV-2 and other viral infections and respiratory diseases in adults and pediatric populations, including SARS-CoV-2/viral coinfections. Design & Methods: RespiDART 2022 will take place in Los Cabos, Mexico over a two-day period, at a location that is easily accessed by both national and international delegates. Mexican doctors (including those servicing the local population) as well as numerous scientists from underdeveloped countries will be invited to attend. The program will include lectures, oral abstract presentations, discussion panels and a poster session. Virtual participation option will be set up in case the ongoing pandemic makes it unsafe to travel to the conference. We believe that RespiDART 2022 is a much needed and timely platform for the discussion of the latest developments in this fast-evolving area of global health.