Network For Emotional Wellbeing And Brain Aging (NEW Brain Aging)

项目摘要：早期的证据表明，情感（eudaimonic和hedonic）之间的联系， 存在（EWB）和潜在的大脑过程，这些过程随着正常和 病理性脑老化然而，这些协会的性质，EWB及其 成分域随着大脑老化而变化，以及这些变化如何与常见的 神经病理学如阿尔茨海默病和相关痴呆症（ADRD）在很大程度上未被探索。客观 情绪健康和大脑老化网络（新的大脑老化）是解决优先领域#2 - 关于情绪健康在健康中的作用的机制研究-RFA-AT-20-003，识别和测试 脑老化影响EWB的机制以及EWB如何影响ADRD的风险和进展。 综合人类和动物文献，我们的前提是EWB和ADRD之间的关系是 双向--正常和病理变化对EWB的影响，EWB对脑老化的贡献 健康和疾病，如ADRD。此外，我们假设EWB和大脑之间的关系 反映了与年龄相关的大脑异质性（即，恢复力、典型衰老或神经病理学 变化），并通过评估和适应过程进行调解。为此，我们将组建一个全国性的， 跨学科合作，包括代表人类和动物研究专业知识的研究人员 神经影像学、应激调节、ADRD研究、EWB和计算/定量方法。具有方向 在执行委员会和外部咨询委员会的指导下，新的大脑老化将承担 这些具体目标：（1）建立一个跨大学和跨学科的合作，高年级和低年级 研究人员对脑，衰老和EWB研究感兴趣，来自人类和动物领域;（2）形成一个 由该领域有关专家组成的一系列有时限的工作组，每个工作组工作1-2年， 新的脑老化活动在三个一般领域的优先事项：（a）EWB的脑机制研究; (b)研究EWB对ADRD的影响;（c）转化动物和跨物种脑研究方法; (3)整合和协调资源，确保大脑相关EWB的严谨性和可重复性 （4）通过严格的同行审查提供三种类型的试点资金： 初级教员与脑机制研究有关的EWB和痴呆症之间的关系，使用 人类或动物模型;（B）为已建立的研究人员提供概念验证赠款，以测试与EWB有关的方面 （c）为跨物种大脑研究提供种子合作赠款 （5）通过跟踪网络的活动、资源使用和生产率来评估网络， 在整个4年拨款期间进行协作网络密度分析;以及（6）确保广泛的 传播新的脑老化产品。通过实现这些目标，我们将加强研究 网络，侧重于EWB的脑机制的理解和EWB和ADRD之间的关系。

Project summary: Early evidence indicates an association between emotional (eudaimonic and hedonic) well- being (EWB) and underlying brain processes, and that those processes change with both normal and pathological brain aging. However, the nature of these associations, the mechanisms by which EWB and its component domains change with brain aging, and how those changes may be associated with common neuropathologies like Alzheimer’s disease and related dementias (ADRD), are largely unexplored. The objective of the Network for Emotional Well-being and Brain Aging (NEW Brain Aging) is to address priority area #2 – mechanistic research on the role of emotional well-being in health – of RFA-AT-20-003, identifying and testing mechanisms by which brain aging influences EWB and how EWB may impact risk for and progression of ADRD. Synthesizing human and animal literature, our premise is that relationships between EWB and ADRD are bidirectional – normal and pathological changes in aging brain influence EWB and EWB contributes to brain health and illness, such as ADRD. Further, we hypothesize that the relationships between EWB and the brain in older adults reflect aging-associated heterogeneity of brain (i.e., resilience, typical aging, or neuropathological changes), and that they are mediated by processes of appraisal and adaptation. To do so we will form a national, transdisciplinary collaborative that includes investigators representing research expertise in human and animal neuroimaging, stress regulation, ADRD research, EWB, and computational/quantitative methods. With direction of an Executive Committee and guided by an External Advisory Committee, NEW Brain Aging will undertake these specific aims: (1) To build an inter-university and transdisciplinary collaborative of senior and junior investigators interested in brain, aging, and EWB research from both human and animal fields; (2) To form a series of time-limited workgroups with relevant experts in the field, each working over 1-2 years, to establish priorities for NEW Brain Aging activities in each of three general areas: (a) brain mechanism research of EWB; (b) research of EWB’s impact on ADRD; and (c) translational animal and cross-species brain research methods; (3) To coalesce and coordinate resources to ensure the rigor and reproducibility of the brain-related EWB research; (4) To provide three types of pilot funding through rigorous peer review: (a) pilot research grants for junior faculty related to brain mechanism studies related to the relationship between EWB and dementia using human or animal models; (b) proof-of-concept grants for established investigators to test aspects related to EWB in their existing studies and cohorts of brain aging; (c) seed collaboration grants for cross-species brain research related to EWB; (5) To evaluate the network by tracking its activities, resource usage, and productivity, and conducting collaborative network density analysis throughout the 4-year grant; and (6) to ensure the wide dissemination of NEW Brain Aging products. By accomplishing these aims, we will strengthen a research network focusing on the brain mechanistic understanding of EWB and relationship between EWB and ADRD.