Child Health Research Career Development Award (CHRCDA) Program at Children's National

摘要 儿童健康研究职业发展奖（CHRCDA）计划的目的 国家医院（CNH）旨在促进成功的基础，转化和临床研究的发展 为T0-T4范围内的儿科初级教员提供职业生涯。该计划的基本原理是 尽管存在许多利用分子生物学、生物医学工程和转化科学的机会， 以先进的儿科疾病治疗，全面的科学知识和实践经验， 在年轻的儿科医生研究者中， 他们最近完成了长期的临床培训。CNH的CHRCDA通过以下方式满足这一需求： 为初出茅庐的科学家在最初的学术任命期间提供充足的受保护的时间。在我们 计划，学者将：1）采取在基础，转化或临床科学领域的课程与他们的 研究; 2）学习最先进的实验室和计算方法; 3）开发初步数据 在既定和承诺的导师的监督下，这将导致提交独立的NIH 资助申请; 4）学习有效地推进基础，翻译和临床方面的成就 研究如何改善儿童健康。为了实现这些目标，CHRCDA学者将 在既定调查员/导师的指导下，花费至少75%的精力磨练这些技能， 2-4一年（取决于过去的经验和调查领域）。在此期间，每个 上述任务将以系统的方式进行，包括参与研究的核心课程 方法学和生物统计学，负责任地开展研究的培训，以及 在高级研究人员的监督下进行越来越独立的研究。我们将每年资助三名学者 在助理教授的水平，通过积极的推广，提高学者的多样性的具体目标 和招聘。我们将有21位资深导师，分别来自四个科学领域：神经科学、分子生物学、 遗传学、癌症和免疫学以及生物医学工程。行政结构将包括两个 主要研究者/项目总监、培训总监、执行委员会和外部 咨询委员会。该计划的成果将由学者们的产品来衡量。 随后的学术生涯：出版物和独立的外部赠款支持。在这次更新申请中 我们引入了几项创新，包括：扩大资助研究，包括T2-T4科学， 招聘适当的导师骨干，新的管道计划，以增加我们的候选人库 包括两个R38奖项，以资助儿科住院医生的研究，重大的资本投资，包括 新的儿童国家研究和创新校园，适应独特的挑战， 2019冠状病毒病大流行期间的培训，扩大对多样性的承诺，并纳入初级导师 与我们的高级导师配对，以“培训培训师”。

ABSTRACT The purpose of the Child Health Research Career Development Award (CHRCDA) Program at the Children’s National Hospital (CNH) is to facilitate the development of successful basic, translational, and clinical research careers for junior faculty members in pediatrics across the T0-T4 spectrum. The rationale for the program is that while many opportunities exist to use molecular biology, biomedical engineering, and translational science to advance treatment of pediatric diseases, the comprehensive scientific knowledge and practical experience that are required to capitalize on these opportunities are often deficient among young pediatrician-investigators who have recently finished extended periods of clinical training. The CHRCDA at CNH addresses this need by providing sufficient protected time for nascent scientists during their initial academic appointment. In our program, scholars will: 1) take coursework in basic, translational, or clinical science areas relevant to their research; 2) learn state-of-the art laboratory and computational methodologies; 3) develop preliminary data under the supervision of established and committed mentors that will lead to submission of independent NIH grant applications; and 4) learn to effectively advance accomplishments in basic, translational, and clinical research into improvements in child health. In order to accomplish these goals, the CHRCDA scholars will spend at least 75% effort honing these skills under the mentorship of established investigators/mentors over a 2-4 year period (depending on past experience and area of investigation). During this period, each of the above tasks will be addressed in a systematic fashion, including participation in a core curriculum in research methodology and biostatistics, in training in responsible conduct of research, and in performance of increasingly independent research under supervising senior investigators. We will fund three scholars annually at the Assistant Professor level with a specific goal of enhancing scholar diversity through aggressive outreach and recruitment. We will have 21 senior mentors in four scientific affinity groups: neuroscience, molecular genetics, cancer and immunology, and biomedical engineering. The administrative structure will include two Principal Investigators/Program Directors, a Training Director, an Executive Committee, and an external Advisory Committee. The outcomes of this program will be measured by the products of the scholars’ subsequent academic careers: publications and independent external grant support. In this renewal application we introduce several innovations including: expansion of funded research to include T2-T4 science with recruitment of a cadre of appropriate mentors, new pipeline programs to increase our pool of candidates including two R38 awards to fund research among pediatric residents, significant capital investments including the new Children’s National Research and Innovation campus, adaptations for the unique challenges of training during the COVID-19 pandemic, an expanded commitment to diversity, and inclusion of junior mentors to be paired with our senior mentors to “train the trainers.”