Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR)

项目摘要 抗逆转录病毒药物发现、评价和应用研究培训计划（ADEAR）是一个 综合计划，提供在人类基础，转化和临床科学的多学科培训 1型免疫缺陷病毒（HIV）/获得性免疫缺陷综合症（艾滋病）研究。博士后 一位科学家将在牛津大学一个基础广泛的教员小组的指导下接受培训。 科罗拉多、科罗拉多、州立大学和丹佛大学的导师都是谁， 积极参与与发现和评估新的抗逆转录病毒药物或 应用现有的抗逆转录病毒药物治疗和预防艾滋病毒/艾滋病。 T32赠款资金的申请将使ADEAR成为一个新的研究培训计划， 提供互动式博士后研究培训，培养全面的实验室和临床科学家， 能够更好地解决结束全球艾滋病流行所需的知识差距。促进 为ADEAR学员提供多学科研究机会，该计划已聘请经验丰富， 艾滋病毒/艾滋病问题的调查人员作为受训人员的导师。可提供的指导培训领域， 学员包括通过基础和转化科学发现抗逆转录病毒药物， 抗逆转录病毒药物，以及抗逆转录病毒药物在临床和社区环境中的应用。拟议程序 包括以下创新功能： 托马斯坎贝尔，医学博士，一位经验丰富的临床研究者和导师，以及Mamuka Kvaratskhelia， 哲学博士、一位经验丰富的基础科学家和导师将担任联合项目主任。 在该计划中整合HIV临床研究者和HIV基础/转化科学家途径 以更好地满足不同研究背景和职业道路的学员的培训需求。 * 制定强有力的计划，促进从附属机构内部和 其他科罗拉多以外的机构 一个正式的计划，以提高项目教师的指导技能。 促进实习生职业生涯的措施，如NIH资助的独立调查员，包括所需的 个人职业发展计划;明确定义的职业发展“可交付成果”，包括 研究出版物和提交K奖申请的要求;以及提供最多3个 为学员提供多年的支持，以确保有足够的时间开发K应用程序。 对项目进度进行内部和外部审查的稳健方法，以及调整 培训课程，以更好地满足学员的需要。 拟议的博士后培训计划将配备良好，以培养基础和临床科学家， 不同的学科，为他们的合作研究生涯做好准备，从而培养出具有 在使用抗逆转录病毒药物作为消除艾滋病毒/艾滋病的工具方面，填补知识空白所需的技能。

PROJECT SUMMARY The Training Program for Antiretroviral Discovery, Evaluation and Application Research (ADEAR) is an integrative program that provides multidisciplinary training in basic, translational and clinical science in human immunodeficiency virus type 1 (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Postdoctoral scientist will receive training under the direction of a broadly based group of faculty at the University of Colorado, Colorado State University and the University of Denver who are who experienced mentors and actively engaged in research related to the discovery and evaluation of new antiretroviral drugs or the application of existing antiretrovirals for the treatment and prevention of HIV/AIDS. This application for T32 grant funding will establish ADEAR as a new research training program that will provide interactive postdoctoral research training to produce well-rounded laboratory and clinical scientists who are better able to address the knowledge gaps needed to end the global AIDS epidemic. To foster multidisciplinary research opportunities for ADEAR trainees, the program has engaged experienced and productive HIV/AIDS investigators as mentors for trainees. The areas of mentored training available to trainees include antiretroviral discovery through basic and translational science, clinical evaluation of antiretrovirals, and application of antiretrovirals in clinical and community settings. The proposed program includes the following innovative features:  Thomas Campbell, M.D., an experienced clinical investigator and mentor, and Mamuka Kvaratskhelia, Ph.D., an experienced basic scientist and mentor will serve as Co-Program Directors.  Integrated HIV Clinical Investigator and HIV Basic/Translational Scientist pathways within the program to better meet the training needs of trainees with diverse research backgrounds and career paths.  A robust plan to facilitate recruitment of trainees both from within the affiliated institutions and from other institutions outside of Colorado.  A formal plan to improve the mentoring skills of program faculty.  Measures to facilitate trainee careers as NIH funded independent investigators including a required individual Career Development Plan; clearly defined career development “deliverables” including research publications and requirement of submission of a K award application; and provision of up to 3 years of support to trainees to ensure sufficient time to develop a K application.  Robust methods for internal and external review of program progress and procedures for adjusting the training curriculum, if necessary, to better meet the needs of trainees. The proposed postdoctoral training program will be well equipped to train basic and clinical scientists from diverse disciplines, prepare them for collaborative research careers, and thereby produce investigators with the skills needed to fill knowledge gaps in the use of antiretrovirals as tools to end HIV/AIDS.