Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY)

摘要 阿片类药物使用障碍(OUD)仍然是一种持久的公共卫生危机和流行病。尽管有强大的全国性， 国家和地方对这一流行病的公共卫生反应，阿片类药物过量死亡人数继续增加； 据疾病控制和预防中心(CDC)报告，2020年有91,799人死于药物过量 大多数，68,630人(75%)涉及阿片类药物，比2019年增加了38%。阿片类药物过量死亡负担 肯塔基州甚至更高，从2019年(n=1036)到2020年(n=1688)，增长了63%。在此背景下 动态变化的阿片类药物流行，因新冠肺炎大流行带来的挑战而变得复杂， 负责监测和改善人口健康的机构和组织需要及时 州和地方数据，以作出关于资源分配和有针对性的响应的关键决策。这样的决定 通常与一套旨在防止阿片类药物过量死亡的循证做法(EBP)有关。 我们将利用肯塔基大学(英国)研究的基础设施和方法专业知识 中心(包括肯塔基州伤害预防和研究中心，药物和酒精研究中心， 和生物医学信息学研究所)，以及我们从治疗工作中获得的经验 由国家药物滥用研究所支持的社区研究，以及将过量数据转化为行动 由疾病预防控制中心赞助的项目。该项目的具体目标是为以下项目建立快速可操作的数据 肯塔基州阿片类药物反应(RADOR-KY)--全州范围内以人口为基础、接近实时的综合阿片类药物反应 将从多个州机构获取数据并实施高级信息学的监视系统 用于快速数据处理、数据链接、机器学习和预测分析的算法，以缩短时间 在数据捕获和分析结果可用于支持阿片类药物过量预防和 控制力。RADOR-KY将拥有移动和基于网络的应用程序，以提供即时传播和 访问接近实时的社区或州级别数据、报告和可视化分析，以与机构和 社区最终用户。RADOR-KY最终用户咨询小组，包括州政府和地方政府的合作伙伴 将指导RADOR-KY报告和可视化功能的开发。RADOR- KY将建立一个纵向数据集，可通过RADOR-KY门户访问，也可在Hear内共享 数据生态系统。已实施的算法和基于Web的仪表板的编程代码将在 一个公共储存库，以推动缓解阿片类药物在美国各地流行的努力。

Abstract Opioid use disorder (OUD) remains a persistent public health crisis and epidemic. In spite of robust national, state, and local public health responses to the epidemic, opioid overdose deaths continue to increase; of the 91,799 drug overdose deaths in 2020, reported by the Centers for Disease Control and Prevention (CDC), the majority, 68,630 (75%) involved opioids, a 38% increase from 2019. The opioid overdose death burden in Kentucky is even higher, with a 63% increase from 2019 (n=1,036) to 2020 (n=1,688). In the context of the dynamically changing opioid epidemic, complicated by the challenges presented by the COVID-19 pandemic, agencies and organizations responsible for monitoring and improving the health of the population need timely state and local data to make critical decisions on resource allocation and targeted responses. Such decisions are typically related to a set of evidence-based practices (EBPs) aimed at preventing opioid overdose mortality. We will harness the infrastructure and methodological expertise at the University of Kentucky (UK) research centers (incl. the Kentucky Injury Prevention and Research Center, the Center on Drug and Alcohol Research, and the Institute for Biomedical Informatics), along with the experience gained from our work on the HEALing Communities Study supported by the National Institute on Drug Abuse, and the Overdose Data to Action project sponsored by the CDC. The specific aims of this project are to establish the Rapid Actionable Data for Opioid Response in Kentucky (RADOR-KY)– an integrated, population-based, near-real time statewide surveillance system that will ingest data from multiple state agencies and implement advanced informatics algorithms for fast data processing, data linkage, machine learning and predictive analytics to shorten the time between data capture and when analytical results are available to support opioid overdose prevention and control. RADOR-KY will have mobile and web-based applications to provide immediate dissemination and access to near-real time community or state level data, reports, and visual analytics to share with agencies and community end-users. RADOR-KY End-user Advisory Group, including partners in state government and local communities, will guide the development of the RADOR-KY reporting and visualization functionality. RADOR- KY will establish a longitudinal dataset accessible thru the RADOR-KY portal and also shared within the HEAL Data Ecosystem. Programming code for implemented algorithms and web-based dashboards will be shared in a public repository to advance the efforts to mitigate the opioid epidemic across the U.S.