Integrated Biostatistical Training for CVD Research

项目摘要/摘要 本申请建议更新生物统计学博士前培训的综合方案，重点是 培训学员为心血管疾病研究的职业生涯做准备。对高技能人才不断增长的需求 具备应对心血管疾病研究中持续挑战和新挑战能力的生物统计学家 用于开箱即用的培训。拟议的项目正式整合了多学科、 协作环境；掌握严格应用所需的统计学理论基础 先进的生物统计技术和新方法的发展；以及 沟通和领导能力。该计划将是北方统计局的共同努力 卡罗莱纳州立大学(北卡罗来纳州立大学)，杜克大学生物统计和生物信息学系(B&B)， 和杜克临床研究所(DCRI)。它利用了两家公司之间的长期合作伙伴关系 博士项目和世界上最大的学术临床研究机构，拥有国际知名的 处于心血管疾病及相关研究前沿的研究人员。五年计划将支持 北卡罗来纳州国务院的5个实习生职位和杜克大学1-3年级的2个职位和4-5年级的3个职位 B&B，平均聘期2-3年。此外，NC State还将提供两个附加匹配 培训机会和DCRI每年将为从培训赠款资金过渡的受训人员提供两个额外的培训机会。 每个机构的实习生将严格学习统计理论，包括概率、推断、线性 和其他统计模型、高级概率和高级统计推断；以及统计方法， 包括临床试验设计/分析、纵向数据分析、生存分析和前沿话题，如 作为与生物医学大数据相关的记录链接、机器学习、并行计算。他们还将收到 生物学和心血管医学基本方面的培训以及研究责任和 道德；以及广泛的正式和经验的沟通和领导技能培训。实习生将是 逐步引入DCRI心血管疾病研究并演变为完全合作的学徒制度 在其中，他们被整合为DCRI项目团队的职能成员。通过这段学徒生涯和 正规课程和研讨会，学员将获得相当多的心血管医学工作知识。 这将使他们在完成后立即为心血管疾病研究做出贡献 这个项目。每个受训人员将被分配一个由一名生物统计学家组成的跨机构指导小组 北卡罗来纳州和B&B每个州的导师和一名主要隶属于DCRI的临床医生导师，这将 通力合作，在各个方面引导他们。论文研究将涉及发展和评估。 在学员合作中遇到挑战的启发下，提出了新的统计方法。实习生将 受益于接触两个机构的不同文化，拓宽了他们的视角和机会 课程、研讨会和其他资源。

PROJECT SUMMARY/ABSTRACT This application proposes renewal of an integrated program for predoctoral training in biostatistics, focused on preparing trainees for careers in cardiovascular disease research. The escalating demand for skilled biostatisticians equipped to address ongoing and emerging challenges in cardiovascular disease research calls for out-of-the-box training. The proposed program formally integrates extensive experiences in multidisciplinary, collaborative environments; mastery of the theoretical underpinnings of statistics required for rigorous application of sophisticated biostatistical techniques and development of new methodology; and strong underpinnings in communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NC State), the Duke University Department of Biostatistics and Bioinformatics (B&B), and the Duke Clinical Research Institute (DCRI). It capitalizes on the long-standing partnership between the two doctoral programs and the largest academic clinical research organization in the world, with internationally known researchers at the forefront of cardiovascular disease and related research. The five-year program will support five trainee positions in the NC State Department and two positions in Years 1-3 and three in Years 4-5 in Duke B&B, with average duration of appointment 2-3 years. In addition, NC State will provide two additional matching slots and DCRI will provide two additional slots in each year for trainees transitioning from training grant funding. Trainees at each institution will pursue rigorous study of statistical theory, including probability, inference, linear and other statistical models, advanced probability, and advanced statistical inference; and of statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge topics, such as record linkage, machine learning, parallel computing relevant to biomedical Big Data. They will also receive training in fundamental aspects of biology and cardiovascular medicine as well as research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually and evolve to full collaborative apprenticeships in which they are integrated as functioning members of DCRI project teams. Through this apprenticeship and formal courses and seminars, trainees will develop considerable working knowledge of cardiovascular medicine that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Each trainee will be assigned an inter-institutional mentorship team comprising a biostatistician mentor at each of NC State and B&B and a clinician mentor whose primary affiliation is at DCRI, which will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees’ collaborations. Trainees will benefit from exposure to different cultures across both institutions, broadening their perspectives and access to courses, seminars, and other resources.