Mentored Patient-Oriented Research for Preventing ASCVD Events

项目摘要/摘要Mora博士是一位在流行病学方面接受交叉培训的心脏病专家，她的职业生涯致力于心血管预防方面的以患者为导向的研究(POR)，专注于心脏代谢性疾病风险的脂质生物标记物的发现和翻译应用，并开发预防心脏代谢性疾病的创新方法和疗法。她的POR研究影响了国内和国际的临床实践指南，在第一个K24周期中，她在与血脂、他汀类药物和心血管风险相关的POR项目中指导了15名博士后和博士后实习生。近年来，她的学员在国内和国际上展示他们的工作所取得的成就突显了这一点，K24续展奖将使她能够延长她成功的导师计划。这一K24奖项的总体目标是：1)通过将高通量代谢组学的技术进步与临床和健康记录数据结合起来，作为改善心血管结果的策略，为下一代心血管研究人员提供精确的POR预防机会，从而发展和扩大她的POR计划；以及2)通过扩大她的POR计划，检查导致过早心血管事件的心脏代谢风险因素，加强和扩大她的全球心血管健康指导计划。心血管疾病仍然是全球头号死亡原因，70%的病例可归因于心脏代谢风险因素。心脏代谢危险因素不受控制的患者患早产和复发心血管事件的风险很高。候选人正在进行的POR项目、卓越的机构资源以及具有成本效益的本地和国际合作为POR心血管研究领域的初级研究人员的培训和职业发展提供了一个良好的环境。该奖项中提出的新研究目标将审查来自不同患者群体的具有心血管疾病风险的靶向代谢组学小组，以更好地了解心脏代谢风险因素如何成为精确的预防性诊断和治疗目标。这项研究计划将为初级研究人员和受训人员提供绝佳的POR机会，以指导他们进行全面的临床、流行病学和分子研究。这一有指导的POR计划的结果将指导未来针对心血管筛查、风险分层以及可能更有针对性的精准医学干预以改善心血管健康的努力。为此，这项K24奖项将促进莫拉博士的受训者成为下一代以患者为导向的独立心血管研究人员。

Project Summary/Abstract Dr, Mora is a cardiologist cross-trained in epidemiology who has devoted her career to patient-oriented research (POR) in cardiovascular prevention, focusing on the discovery and translational applications of lipid biomarkers of cardiometabolic disease risk, and developing innovative approaches and therapies for preventing cardiometabolic disease. Her POR research has impacted national and international guidelines for clinical practice, In the first K24 cycle, she has mentored more than fifteen preand postdoctoral trainees in POR projects related to lipids, statins, and cardiovascular risk. This has been highlighted in recent years by the achievements of her mentees in presenting their work nationally and internationally, The K24 renewal award will allow her to extend her successful mentoring program. The overall goals of this K24 award are to 1) grow and expand her POR program by providing the next-generation of cardiovascular investigators with opportunities for precision POR in prevention by incorporating technologic advances in high-throughput metabolomics with clinical and health record data as a strategy to improve cardiovascular outcomes; and 2) strengthen and build upon her mentoring program in global cardiovascular health by expanding her POR program to examine cardiometabolic risk factors contributing to premature cardiovascular events. Cardiovascular disease remains the number one cause of death globally, and > 70% of cases can be attributed to cardiometabolic risk factors. Patients with uncontrolled cardiometabolic risk factors are at high risk of suffering from premature and recurrent cardiovascular events. The candidate's ongoing POR projects, exceptional institutional resources, and cost-effective local and international collaborations provide a nurturing environment for the training and career development of junior investigators in POR cardiovascular research. The new research aims proposed in this award will examine a panel of targeted metabolomics with risk of cardiovascular disease from diverse patient populations to better understand how cardiometabolic risk factors could be targeted for precision preventative diagnostic and therapeutic targets. This research program will provide excellent POR opportunities for junior investigators and trainees to be mentored across the full spectrum of clinical, epidemiological, and molecular studies. Results from this mentored POR program will guide future efforts directed at cardiovascular screening, risk stratification, and potentially more targeted precision medicine interventions to improve cardiovascular health. Towards that end, this K24 award will facilitate the progress of Dr, Mora's mentees into the next generation of patient-oriented independent cardiovascular researchers.