Speech Profiles and Cue Responsiveness After Left Hemisphere Stroke

摘要 年约200万失语症患者中的大多数都有言语产出困难。 美国。言语障碍的行为表现是多种多样的 与当前的鉴别诊断系统不完全归类。虽然是定制的 人们普遍认为，基于不同语音特征的治疗可以改善交际能力 能力和生活质量，循证实践由于不明确的诊断而受到限制 关于哪些语音特征在核心障碍中区分的过程和不确定性 类别(言语失用、失语伴音素性失语、单侧上肢运动 神经性构音障碍)，因为它们是行为学上的定义。在这个项目中，我们介绍了一个系统 临床相关语音特征的定量记录和分析。这个 目标1的目的是开发一种用于记录语音配置文件和 估计他们的严重程度。我们界定了正常语言和受损语言之间的界限 跨关键维度和指标进行生产，并确定心理测量学上的健全和 评估严重程度和表征多维语音的临床可行测试 配置文件。在目标2中，我们通过实验为语音特征文件开发了一种量化签名 重点分析。通过用经验验证的简档替换现有的诊断核对表， 我们预计项目成果将解决持续了几十年的诊断混乱问题。 在目标3中建立了诊断和干预之间的联系，以便建立 精准干预研究的基础。该项目预计将产生声音 评估和诊断程序，消除科学发现的根本障碍 关于中风后言语产生困难的问题。

ABSTRACT Speech production difficulties affect most of the approximately 2 million people with aphasia in the United States. Behavioral manifestations of speech impairment are heterogeneous and imperfectly categorized with current systems for differential diagnosis. Though customized treatment based on different speech profiles is widely believed to improve communicative abilities and quality of life, evidence-based practice is limited due to a poorly defined diagnostic process and uncertainty about which speech features distinguish among the core disorder categories (apraxia of speech, aphasia with phonemic paraphasia, unilateral upper motor neuron dysarthria), as they are defined behaviorally. In this project, we introduce a system for quantitative documentation and analysis of clinically relevant speech characteristics. The purpose of Aim 1 is to develop a new assessment for documenting speech profiles and estimating their severity. We define boundaries between normal and impaired speech production across key dimensions and metrics and identify a psychometrically sound and clinically feasible test for estimating severity and characterizing multidimensional speech profiles. In Aim 2, we develop a quantitative signature for speech profiles through empirically focused analyses. By replacing existing diagnostic checklists with empirically validated profiles, we expect project outcomes will resolve diagnostic confusion that has persisted for decades. The link between diagnosis and intervention is developed in Aim 3, in order to establish a foundation for precision intervention research. The project is expected to generate sound assessment and diagnostic procedures and remove fundamental barriers to scientific discovery concerning speech production difficulties after stroke.