Microbiome Function in Atopic Dermatitis

摘要/摘要 特应性皮炎（AD）是一种常见的炎症性皮肤病。最近的观察强烈表明 存在于AD受试者皮肤上的异常微生物组是影响AD治疗的主要因素。 这种疾病的严重性和慢性性质。特别是，金黄色葡萄球菌促进表皮屏障 功能障碍并加剧局部和全身免疫应答。在健康受试者中， 皮肤微生物组的成员起到限制金黄色葡萄球菌生长的作用，但这些有益的细菌 在AD患者身上没有发现菌株。该项目旨在了解为什么成年AD患者缺乏有益的 通过研究人葡萄球菌的原型菌株在AD皮肤上的存活来确定细菌菌株。 将测试改善其生存率的干预措施，并将在儿童AD人群中应用 评估。总体而言，成功完成ADRN临床研究中心的拟定目标将 促进对AD的理解，并提供必要的信息，以允许开发创新的新 基于靶向微生物组疗法的治疗方法。

Summary/Abstract Atopic dermatitis (AD) is a common inflammatory skin disease. Recent observations strongly suggest that the abnormal microbiome present on the skin of subjects with AD is a major factor that influences the severity and chronic nature of this disorder. In particular, Staphylococcus aureus promotes epidermal barrier dysfunction and exacerbates the local and systemic immune response. In healthy subjects, beneficial members of the skin microbiome act to limit the growth of Staphylococcus aureus but these beneficial bacterial strains are missing on adults with AD. This project seeks to understand why adults with AD lack beneficial bacterial strains by study of the survival of a prototype strain of Staphylococcus hominis on AD skin. Interventions to improve its survival will be tested, and application in the pediatric AD population will be evaluated. Overall, successful completion of the proposed aims of this ADRN Clinical Research Center will advance understanding of AD and provide essential information to permit development of an innovative new therapeutic approach based on targeted microbiome therapy.