Mechanics and Devices

抽象-核心B 核心B的目标是为调查人员提供最先进的仪器和其他资源 研究骨骼肌发育和疾病，2)早期肌肉细胞成熟的检测，以及 3)测试和开发新的治疗干预措施。核心有评估收缩的仪器 在蛋白质、细丝、细胞、组织和器官水平上的功能以及测量发育的方法 动物和人类早期肌肉的特性，如可诱导的多能干细胞 衍生的肌肉细胞。核心将单独和与研讨会一起培训调查人员，并与他们合作 为药物和小分子测试开发新的研究分析方法，并研究工程细胞和 正在为临床应用和商业化而开发的组织和基因疗法。

ABSTRACT – Core B The goals of Core B is to provide 1) state of the art instrumentation and other resources to investigators studying skeletal muscle development and diseases, 2) assays for maturation of early stage muscle cells, and 3) testing and developing novel therapeutic interventions. The Core has instrumentation to assess contractile function at the protein, filament, cell, tissue and organ levels, and assays for measuring the developing properties of early stage muscle from animal and human sources such as inducible pluripotent stem cell derived muscle cells. The Core will train investigators individually and with workshop, and work with them to develop novel research assays for drug and small molecule testing, and investigating engineered cells and tissues and gene therapies that are being developed for clinical application and commercialization.