UW Center for Translational Muscle Research (Overall Application)

摘要--总体 华盛顿大学(UW)因其在骨骼肌各方面的卓越表现而闻名国际 生物学，尤指疾病的机械学和转化学研究。然而，目前还没有 集中资源，将来自多个部门的所有肌肉调查人员聚集在一起，以实现 为他们的努力提供便利和加速。因此，我们建议成立UW翻译资源中心 肌肉研究(CTMR)提供统一的资源和最先进的方法来增强骨骼 威斯康星大学的肌肉研究。拟建的中心将提供工具、设施和专业知识 仅在威斯康星州大学提供，以促进对肌肉病理的新见解，并推动新疗法走向 诊所和市场。这个新中心将提供4个核心(一个管理核心和三个研究核心 资源)，为目前的主要调查人员提供若干感兴趣的领域的工具和专门知识。这个 行政核心(A)将通过提供试点项目计划来提供计划管理和丰富， 讲习班、系列研讨会、为新调查员和更有经验的调查员提供培训和教育机会 研究人员进入肌肉研究领域。机械和设备核心(B)将提供最先进的 多层次整合的肌肉生物力学测量，并开发新的成熟测试方法 以及对早期肌肉的评估。新陈代谢和能量核心(C)将提供深入的工具 代谢组学、能量学、细胞呼吸和线粒体功能的测量和分析。这个 计算和定量分析核心(D)将提供以下计算和统计工具 了解疾病，提出新的治疗靶点和了解机制。CTMR将 提供一个环境，便于使用从单分子动力学到肌肉的综合分析 结构-功能关系，以跨学科方法推进骨骼肌疾病研究 和治疗学的发展。

ABSTRACT - Overall The University of Washington (UW) is internationally known for its excellence in all aspects of skeletal muscle biology, especially in mechanistic and translational research of diseases. However, there is currently no centralizing resource that brings together all the muscle investigators from multiple departments for the benefit of facilitating and accelerating their efforts. Therefore we propose the UW Resource Center for Translational Muscle Research (CTMR) to provide a unifying resource and state of the art approaches to enhance skeletal muscle research at the UW. The proposed Center will offer tools, facilities and expertise in a combination available only at the UW to facilitate novel insights to muscle pathologies and move new therapeutics towards the clinic and the marketplace. This new Center will offer 4 cores (one administrative and three research resource) to provide tools and expertise in several areas of interest to current principal investigators. The Administrative Core (A) will provide program management and enrichment by providing a pilot project program, workshops, a seminar series, training and educational opportunities for new investigators and more experienced investigators moving into muscle research. The Mechanics and Devices Core (B) will provide state of the art measurements of muscle biomechanics at multiple levels of integration, and develop new assays for maturation and assessment of early stage muscle. The Metabolism and Energetics Core (C) will provide tools for in depth measures and analysis of metabolomics, energetics, cell respiration and mitochondrial function. The Computational and Quantitative Analysis Core (D) will provide computational and statistical tools for understanding disease, suggesting new therapeutic targets and understanding mechanisms. The CTMR will offer an environment to facilitate using integrative analysis, from single molecule dynamics through muscle structure-function relationships, with interdisciplinary approaches to advance skeletal muscle disease research and therapeutics development.