Pathophysiology and Rehabilitation of Neural Dysfunction

项目摘要 这项提案寻求为我们病理生理学和康复训练计划的第七个周期提供资金 神经功能障碍(PRND)。该项目的总部设在西北大学，与 雪莉·瑞安能力实验室。该片由Eric Perreault博士执导，Levi Hargrove博士联合执导， Lee Miller博士和Elliot Roth医学博士。学员将由26名高度协作和富有成效的学员指导 来自工程学和医学系七个系的科学家。该小组拥有广泛的专业知识 神经功能障碍的病理生理学和康复，从细胞神经生理学到 从新技术、新材料和新机器的工程到临床实施。在这一生中 方案中，49名博士后研究员、36名博士后研究员和17名暑期实习生得到了支持 在经济上，还有200多人从我们的T32活动中受益。大多数受训人员仍留在学术界， 许多人现在是康复医学领域的老牌领导者。我们的使命是培养未来的研究人员 来自工程学和基础科学，对残疾的基本机制进行研究 神经疾病，以指导开发有临床意义的工具来量化和缓解 神经疾病的严重性和影响，并继续研究康复干预对 致残性疾病。我们的培训从以患者为中心的临床体验开始，从而提供 未来研究的背景。临床经验的补充是通过科学的机制培训。 神经功能障碍，从实验室向患者转让技术的信息，以及几个 开展专业和网络发展活动，为学员在康复领域从事富有成效的职业生涯做好准备 科学。在这次续订申请中，我们的目标是在过去成就的基础上，通过以下方式提高我们的影响力 增强功能将扩大我们接触到的科学家社区，完善我们提供的临床经验， 增加调查的严谨程度，并加强专业发展机会，以促进 从实习生过渡到独立科学家。我们计划培养三名博士后研究员，三名博士后 研究员和两个暑期实习生。这比我们目前增加了一名博士后研究员和一名实习生 水平，反映了我们研究能力的增长。博士前实习生将从丰富的 申请参加的工程系(生物医学、计算机科学、材料科学和 机械)。博士后研究员将从这些相同的部门中挑选，并从医学 物理医学和康复、物理治疗和人体运动科学系，以及 生理学。所有参与者都将完成两年的培训。通过将提议的创新与 虽然已经有了成功的做法，但我们希望继续推进康复的科学和实践。 通过培养下一代跨学科的领导者来培养医学。

Project Summary This proposal seeks funding for the seventh cycle of our training program in Pathophysiology and Rehabilitation of Neural Dysfunction (PRND). The program is based at Northwestern University, in close collaboration with the Shirley Ryan AbilityLab. It is directed by Dr. Eric Perreault, PhD, and co-directed by Drs. Levi Hargrove, PhD, Lee Miller, PhD and Elliot Roth, MD. Trainees will be mentored by 26 highly collaborative and productive scientists from seven departments in engineering and medicine. This group has broad expertise relevant to the pathophysiology and rehabilitation of neural dysfunction, ranging from cellular neurophysiology to the engineering of novel techniques, materials, and machines, to clinical implementation. Over the life of this program, 49 predoctoral fellows, 36 postdoctoral fellows, and 17 summer interns have been supported financially, and more than 200 others have benefitted from our T32 activities. Most trainees remain in academia, and many are now established leaders in rehabilitation medicine. Our mission is to train prospective researchers from engineering and the basic sciences to perform research on fundamental mechanisms underlying disabling neurological illness, to guide the development of clinically meaningful tools for quantifying and relieving the severity and impact of neurologic illness, and to pursue research on the effects of rehabilitation interventions on disabling illnesses. Our training begins with a clinical experience centered on the patient, thereby providing context for future research. The clinical experience is supplemented by scientific training in the mechanisms of neurological dysfunction, information on technology transfer from the laboratory to the patient, and several professional and network development activities to prepare our trainees for a productive career in rehabilitation science. In this renewal application, we aim to build on our past achievements and increase our impact through enhancements that will broaden the community of scientists we reach, refine the clinical experience we provide, increase the rigor of our inquiry, and strengthen the professional development opportunities facilitating the transition from trainee to independent scientist. We propose to train three predoctoral fellows, three postdoctoral fellows and two summer interns. This is an increase of one postdoctoral fellow and one intern over our current levels, reflecting growth in our research capacity. Predoctoral trainees will be selected from the rich pool of applicants in the participating engineering departments (Biomedical, Computer Science, Materials Science, and Mechanical). Postdoctoral fellows will be selected from these same departments, and from the medical departments of Physical Medicine and Rehabilitation, Physical Therapy and Human Movement Sciences, and Physiology. All participants will complete two years of training. By integrating the proposed innovations with the successful practices already in place, we expect to continue advancing the science and practice of rehabilitation medicine by training the next generation of interdisciplinary leaders.