Administrative Core

核心A摘要 行政核心的目的是监督各实验室的行政职责 本P01项目1、2和3中概述的研究。行政核心将提供高层次的 为项目提供组织支持，包括提供必要的资源、财政监督、遵守 机构和NIH指南/法规。行政核心将进一步协调定期联合 会议，传播成果，讨论科学挑战，并发现创新的解决方案，以推动 科学行政核心将用于整合样本收集和临床因素的科学努力 通过（i）协调样本跟踪和（ii）检索和 与DFCI内外的机构一起为所有3个项目收集数据。行政核心还 负责提交/维护与样本相关的监管文件。的 行政核心将进一步促进重大研究成果迅速传播给科学界， 社区这些活动将有助于加强联合国系统内部和系统之间丰富的科学努力的整合。 项目，并促进将结果转化为患者护理环境;相反， 实验室研究源自所有3个项目中获得的临床观察和组织样本。总之， 这一项目的中心资源将加强调查小组之间的互动， 翻译的目标和这个计划的整合基因组，功能和临床信息的愿景， 里希特综合征患者

Core A Summary Abstract The purpose of the Administrative Core is to oversee the administrative responsibilities of the various laboratory studies outlined in the Projects 1, 2 and 3 in this P01. The Administrative Core will provide high-level organizational support for the Projects, including provision of necessary resources, fiscal oversight, adherence to institutional and NIH guidelines/regulations. The Administrative Core will further coordinate regular joint meetings to disseminate results, discuss scientific challenges, and discover innovative solutions to advance the science. The Administrative Core will serve to integrate scientific efforts for sample collection and clinical factor analysis within and between Projects through the (i) coordination of sample tracking and (ii) the retrieval and data collection for all 3 Projects with institutions both within and outside of DFCI. The Administrative Core also has responsibility for the submission/maintenance of regulatory documents related to samples. The Administrative Core will further promote the rapid dissemination of significant research findings to the scientific community. These activities will serve to enhance the integration of the rich scientific efforts within and between Projects, and foster the translation of findings to the patient care setting; and conversely, the initiation of laboratory studies stemming from clinical observations and tissue samples obtained in all 3 projects. Altogether, this central resource for the Projects will enhance interactions among the investigative teams to further the translational goals and vision of this Program for integrating genomic, functional and clinical information of patients with Richter's Syndrome.