Transdisciplinary Research in Energetics and Cancer (TREC) Training Grant

摘要 鉴于肥胖、不良饮食和缺乏体育锻炼的流行率不断上升，这些因素结合在一起被称为"能量"。 平衡"或"能量学"，以及它们与癌症发病率和死亡率的关系，创新研究， 需要临床护理和科学家的培训来降低这些风险因素的患病率， 癌症发病率和死亡率。2020年9月，NCI发布了2022财年预算 建议，其中包括肥胖和癌症作为一个特色的科学课题，并培养下一代的 癌症研究人员作为一个关键的投资。在2016 - 2021年的NCI R25支持下，我们开发并提供了一个 一年一度的为期一周的，在驻地能量学和癌症（TREC）培训课程的跨学科研究， 随后是为期一年的指导计划，重点是能源平衡和癌症研究， 癌症控制连续体。该计划的总体目标是教育、培训和指导100名早期 职业调查员，称为TREC研究员，来自不同的学术背景（即，基础、临床和 人口科学）在能量学和癌症的跨学科研究。在TREC的前四年， 我们从57个不同的机构招收和培训了97名研究员。我们是在我们的TREC计划的第五个年头 预计将再招募20名研究员，总共有117名研究员完成TREC培训计划。 TREC研究员在同行评审期刊上发表了270篇手稿，其中62篇已发表 包括TREC研究员作为第一或高级作者，并包括TREC教师和/或研究员作为合著者。 自完成该方案以来，TREC研究员作为主要研究员已获得31笔校外赠款。 在前五年的基础上再接再厉，但要对更多的培训机会作出反应， 为了进一步推广这门课程，我们竞争性更新的目标是：1）提供一个混合TREC 培训计划与虚拟TREC学院主导的计划之前，面对面的研讨会侧重于 增加内容知识; 2）随后是为期5天的面对面研讨会，重点是研究员的研究， 网络和专业发展;以及3）研究员和教师之间长达一年的导师制 导师和同伴导师。由梅林达欧文博士领导，利用耶鲁大学公共管理学院的资源， 健康，耶鲁癌症中心，和约20名来自全国各地的专家TREC教师和100多名TREC研究员 来自世界各地的校友，我们的TREC计划是创新的，目前没有培训机会存在 专注于能量学和癌症研究我们的目标是继续培训科学家的TREC使命 培养一批训练有素、多元化的研究人员。该计划的总体影响将由以下因素确定： TREC研究员产生创新研究方法和发现的程度，从而 加快传播循证方法并将其落实到日常实践中， 病人护理，从而改善癌症高危人群以及癌症幸存者的健康。

Abstract Given the rising prevalence of obesity, poor diet and physical inactivity, known in combination as “energy balance” or “energetics”, as well as their associations with cancer incidence and mortality, innovative research, clinical care and training of scientists are needed to lower the prevalence of these risk factors and in turn, lower cancer incidence and mortality rates. In September 2020, the NCI released its Fiscal Year 2022 Budget proposal, which includes obesity and cancer as a featured scientific topic and training the next generation of cancer researchers as a key investment. With NCI R25 support from 2016-2021, we developed and offered an annual one-week, in-residence Transdisciplinary Research in Energetics and Cancer (TREC) Training Course, followed by a yearlong mentoring program, that focused on energy balance and cancer research across the cancer control continuum. The overall goals of this Program were to educate, train and mentor 100 early career investigators, called TREC Fellows, from diverse academic backgrounds (i.e., basic, clinical and population sciences) in transdisciplinary research in energetics and cancer. For the first four years of TREC, we admitted and trained 97 Fellows from 57 different institutions. We are in our 5th year of our TREC Program and expect to recruit 20 more Fellows, for a total of 117 Fellows completing the TREC Training Program. TREC Fellows have published 270 manuscripts in peer-reviewed journals, with 62 published manuscripts including the TREC Fellow as first or senior author and including a TREC Faculty and/or Fellow as co-author. Since completing the Program, TREC Fellows have received 31 extramural grants, as principal investigator. Building upon the strengths of the previous five years but responsive to additional opportunities for training and further dissemination of the course, the goals of our competitive renewal are: 1) to offer a hybrid TREC Training Program with virtual TREC Faculty-led programs before the in-person workshop focused on increasing content knowledge; 2) followed by a 5-day in-person workshop focused on the Fellows’ research, networking and professional development; and 3) year-long mentorship between the Fellow and Faculty Mentor and Peer Mentor. Led by Dr. Melinda Irwin and drawing from the resources of the Yale School of Public Health, Yale Cancer Center, and ~20 expert TREC Faculty from across the country and 100+ TREC Fellow alumni from around the world, our TREC Program is innovative in that currently no training opportunity exists that focuses on energetics and cancer research. Our goal is to continue the TREC mission of training scientists to develop a cadre of well-trained, diverse researchers. The overall impact of this program will be defined by the degree to which TREC Fellows produce innovative research approaches and discoveries, thereby accelerating the dissemination and implementation of evidence-based approaches into everyday practice and patient care, in turn improving the health of the population at risk for cancer as well as cancer survivors.