Connectome style neuroimaging in non human primates via novel integrated RF platforms

项目摘要 人类超高场神经成像实现了前所未有的分辨率，首次实现了对体内定向信息处理的非侵入性研究。这些进步源于高分辨率揭示层特异性（前馈、反馈）激活模式的能力。然而，这些工具并没有在模拟人脑功能的翻译模型中得到验证。其原因主要是由于我们目前无法获得足够高分辨率的功能性磁共振成像（fMRI）信号，以解决非人类灵长类动物的层特异性反应。该项目旨在开发新颖和创新的射频硬件，并在10.5特斯拉的超高场强下使用它来直接测试来自fMRI的全脑方向连接估计与地面真实束追踪实验的对应程度。这种发展和验证可以直接帮助我们将动物模型的发现转化为人类精神疾病的介观电路效应的未来研究。

PROJECT SUMMARY Ultra high field neuroimaging in humans enables unprecedented resolutions that enable, for the first time, the non invasive investigation of directional information processing in vivo. These advances result from the ability of high resolutions to uncover layer specific (feedforward, feedback) activation patterns. These tools however are not validated in translational models that mimic human brain function. The reason for that is primarily due to our current inability to obtain functional magnetic resonance imaging (fMRI) signals at resolutions high enough to resolve layer specific responses in the non human primate. This project aims at developing novel and innovative radiofrequency hardware and using it at the ultra high field strength of 10.5 Tesla to directly test how well whole brain directional connectivity estimates from fMRI correspond with ground truth tract tracing experiments. This development and validation can directly aid us in translating findings from the animal model into future studies of the mesoscopic circuit effects of human mental illness.