Regional Centre for Vector Borne Diseases in West Africa (RCVBD)

项目摘要 尽管西非目前面临着前所未有的高水平疟疾， 非洲的能力太低，无法实现控制和消除疟疾的目标。此外，许多新 发达国家开发的技术和工具没有被非洲很好地利用 科学家例如，分子群体遗传学、基因组学和生物信息学方面的新工具， 疾病建模尚未纳入非洲的疟疾研究和控制。低研究 与非洲其他区域相比，西非的能力要差得多。因此，有一个 迫切需要加强西非传染病的研究能力。我们提出 西非病媒传播疾病区域中心（RCVBD），以提高研究能力 通过培训博士生和初级教师， 研究科学家。该联合会的伙伴来自三个西非机构（西非大学和西非大学）。 加纳、冈比亚医学研究理事会单位和 布基纳法索的Santé）。来自三个美国机构的合作者（加州大学欧文分校， 新墨西哥州大学和西北大学）将协助培训计划。整体 该培训计划的目标是通过培训下一个非洲国家， 非洲一代科学家在病媒传播疾病的研究和控制领域， 特别关注疟疾。培训的专题领域包括流行病学、医学昆虫学 以及新的遗传学、基因组学和生态学研究工具的应用。我们提出了三个轨道， 训练轨道1将在西非对8名博士生进行长期培训。轨道2将提供短- 为15名初级大学教员和来自卫生部的初级科学家提供了学期研究培训， 西非的一个项目是培养疟疾研究和控制所需的具体技能。第三阶段将是培训 举办讲习班和短期课程，向广大有关社区传播技术和知识 在西非进行病媒传播疾病研究和控制。本培训计划将侧重于四个方面 迫切需要的科学领域，包括1）疟疾流行病学和昆虫学的新工具 监测，2）抗疟药物对青蒿素和伙伴药物的抗药性，3）人口基因组学 4）疟疾传播动力学模型和疟疾干预 战略布局这项研究培训计划将有助于促进西非科学家的职业生涯， 通过积极的导师制和杰出的研究人员， 出版物，使他们掌握新的知识和技能，并加强他们的合作 与非洲内外的科学家交流。

PROJECT SUMMARY Although West Africa is currently burdened with an unprecedented high levels of malaria, the research capacity in Africa is too low to meet the malaria control and elimination goal. Furthermore, many new techniques and tools developed in the developed countries have not been well utilized by Africa scientists. For example, new tools in molecular population genetics, genomics and bioinformatics and disease modeling have not been integrated into malaria research and control in Africa. Low research capacity in West Africa is far more dire in comparison to other African regions. Therefore, there is an immediate need to strengthen the research capacity in infectious diseases in West Africa. We propose this Regional Centre for Vector Borne Diseases in West Africa (RCVBD) to enhance research capacity in malaria epidemiology and medical entomology through training PhD students and junior faculty and research scientists. The consortium partners are from three West African institutions (University of Ghana, The Medical Research Council Unit Gambia, and Institut de Recherche en Sciences de la Santé of Burkina Faso). Collaborators from three US institutions (University of California at Irvine, University of New Mexico and the Northwestern University) will assist the training program. The overall goal of this training program is to enhance research capacity in West Africa by training the next generation of African scientists in the area of vector-borne disease research and control with a special focus on malaria. The thematic areas of training include epidemiology, medical entomology and application of new genetic, genomic and ecological research tools. We propose three tracks of training. Track 1 will be long-term training of 8 PhD students in West Africa. Track 2 will provide short- term research training to 15 junior university faculty and junior scientists from the Ministry of Health in West Africa to foster specific skills required for malaria research and control. Track 3 will be training workshops and short courses to disseminate techniques and knowledge to wide communities involved in vector borne disease research and control in West Africa. This training program will focus on four scientific areas in urgent need, including 1) new tools for malaria epidemiological and entomological surveillance, 2) antimalarial drug resistance to artemisinin and partner drugs, 3) population genomics of insecticide resistance, and 4) modeling malaria transmission dynamics and malaria intervention strategies. This research training program will help advance the careers of West African scientists by strengthening their academics and research productivity through vigorous mentorship and outstanding publications, equipping them with new knowledge and skills, and enhancing their collaborative opportunities with scientists within and out of Africa.