Training Grant in Circadian and Sleep Research

项目总结/摘要 这是一个更新的应用程序，已建立的NHLBI赞助的T32，“训练补助金在昼夜节律和 睡眠研究”，以培养博士前和博士后学生和研究员在西北大学。的 昼夜节律生物学和睡眠研究的整合一直是这个培训计划的基石， 成立于1998年。Fred Turek博士将成为T32项目的项目总监之一，他一直是该项目的负责人。 20年Phyllis Zee博士也将成为两名项目总监之一（多名PI），以提供 领导增加临床研究培训昼夜节律生物学和睡眠研究的研究员和 西北大学范伯格医学院（FSM）的住院医生将成为领导者， 医生科学家作为他们的职业发展。T32计划将涉及15名初级培训教师， 他们的主要任命在基础科学或临床部门。拟议的培训 该计划将提供博士前和博士后学生跨学科和多学科的培训，在广泛的 一系列与理解功能、调节和健康高度相关的科学学科 睡眠和昼夜节律的影响。该计划的核心是培养学生在现代 基础科学、转化研究以及面向患者的研究。多种研究视角 20多年来，促进了生产力的互动和交叉施肥， 本节目中的主持人。由于我们的国家正面临着前所未有的肥胖症，糖尿病及其 心血管后果，在本申请中提出的训练计划被独特地定位于 培养一支由学术和行业调查人员组成的跨学科队伍， 制造商，以解决睡眠障碍和昼夜节律功能障碍在这些公共卫生挑战中的作用。 我们的培训计划的一个关键特点是包括7个合作学院与其他临床， 科学和/或教育专业知识，大大提高了我们的培训环境。我们的计划将使 培训学员将遗传学，基因组学， 微生物学，内分泌学，代谢，药理学，神经生物学，肺病学，认知神经科学， 老年学和胃肠病学纳入他们在睡眠和昼夜节律研究方面的培训。因为导师们 积极参与分子、细胞、系统、行为和流行病学水平的研究， 学员将在一个丰富的研究活动环境中接受培训， 睡眠机制和生物组织各个层面的昼夜节律功能。我们请求支援 从这个T32更新为4名博士前学生和4名博士后研究员为五年的每一年。我们 我预计每个学生/研究员的培训期为2-3年，但如果学员 通过其他资金来源获得个人支持。值得注意的是，NU研究生院将 为该培训计划的未来5年的每一年提供额外的2名博士生的支持。

Project Summary/Abstract This is a renewal application of an established NHLBI- sponsored T32, “Training Grant in Circadian and Sleep Research”, to train predoctoral and postdoctoral students and fellows at Northwestern University. The integration of circadian biology and sleep research has been the cornerstone of this Training Program from its inception in 1998. Dr. Fred Turek will be one of the Program Directors of this T32 Program, which he has been for 20 years. Dr. Phyllis Zee will also be one of the two Program Directors (Multiple PI), in order to provide leadership for increasing clinical research training in Circadian Biology and Sleep Research for Fellows and residents at the Northwestern University Feinberg School of Medicine (FSM) who will become leading physician scientists as their careers develop. The T32 Program will involve 15 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientific disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of students in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than 2 decades the productive interactions and cross-fertilization that have developed between the preceptors in this Program. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators, as well as government decision makers, to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 7 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, microbiomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology, and gastroenterology into their training in sleep and circadian research. Because the preceptors are actively involved in research at the molecular, cellular, systems, behavioral, and epidemiological levels, trainees will be trained in a rich environment of research activities that are integrated to study of the basic mechanisms of sleep and circadian function at all levels of biological organization. We are requesting support from this T32 renewal for 4 predoctoral students and 4 postdoctoral fellows for each of the five years. We anticipate the training period will be 2-3 years for each student/fellow, although it may be less if a trainee obtains individual support through other funding sources. It should be noted that the NU graduate school will provide support for an additional 2 predoctoral students for each of the next 5 years of this Training Program.