Developing research training in Zambia to address the epidemic of cardiovascular disease and mental illness amongst HIV infected populations.

项目摘要/摘要：这个D 71规划补助金的首要目标是开发一个 D43艾滋病毒感染者心脏病和精神病研究培训方案 参加赞比亚国家艾滋病毒护理和治疗方案的个人。2018年， 1.2赞比亚有100万人感染艾滋病毒1。2016年，男性预期寿命为60岁， 妇女64岁，比2012年的49.4岁有了相当大的增长，部分原因是 改善获得抗逆转录病毒治疗的机会。2、尽管有很多 尽管预期寿命增加，但艾滋病毒感染者的死亡率仍然很高。 非传染性疾病，特别是心血管疾病（包括 高血压性心脏病、心肌梗塞和充血性心力衰竭）、衰老和 精神疾病越来越多地导致中低收入国家的高发病率和死亡率， 低收入国家，如赞比亚。CIDRZ，一个土著研究组织， 赞比亚一直在努力建立和保持高质量、全面的 为全国各地的艾滋病毒感染者提供护理。对艾滋病毒的重大投资 服务（包括PEPFAR）已经产生了一个训练有素，熟练和自信的干部队伍 艾滋病护理提供者和临床医生。然而，他们所受训练的特殊性意味着， 缺乏训练有素的研究人员和调查人员来确定相关的研究 问题，也缺乏有能力和训练有素的临床医生来处理重大的并发症， 包括糖尿病、心血管疾病、衰老以及值得注意的精神健康在内的疾病 问题.最近，这些成果正在被SARS-CoV-2感染的爆发所侵蚀 其对艾滋病毒感染者的影响，特别是在我们资源有限的情况下， 仍然未知。CIDRZ与圣路易斯的华盛顿大学合作，提出 与赞比亚大学、卢萨卡大学、利维·姆瓦那瓦萨医学院合作， 大学，卫生部和国家卫生研究局建立了一个 为正在进行的高质量艾滋病毒/非传染性疾病研究提供培训平台。我们申请资金， 这个D 71准备，并最终构建一个D43，其目标是：1。增加游泳池 合格的、有能力的研究人员和主要研究者; 2.增加和加强 艾滋病毒感染者中本地产生的非传染性疾病流行率和风险因素数据; 3. 制定传播和实施战略; 4.与其他人开展合作 当地和次区域内的研究机构和大学， 现有能力，提高研究能力。

Project Summary/Abstract: The overarching goal of this D71 planning grant is to develop a D43 research-training program in cardiac disease and mental illness amongst HIV infected individuals enrolled in the National HIV Care and Treatment Program in Zambia. In 2018, 1.2 million people in Zambia were living with HIV1. In 2016, life expectancy for men was 60 years and for women 64 years, a considerable increase from 49.4 years in 2012, partly due to improved access to antiretroviral treatment (ART). 2 However, despite the considerable increase in life expectancy, mortality amongst the HIV infected population remains significant. Non-communicable diseases (NCDs), in particular cardio-vascular disease (incorporating hypertensive heart disease, myocardial infarction and congestive cardiac failure), aging and mental illness are increasingly responsible for high morbidity and mortality in low- and middle- income countries (LMICs) such as Zambia. CIDRZ, an indigenous research organization in Zambia, has been leading the efforts to establish and maintain high quality, comprehensive care for HIV infected individuals across the country. The significant investment into HIV services (including PEPFAR) have resulted in a cadre of well trained, skilled and confident HIV care providers and clinicians. However, the specificity of their training has meant that there is a dearth of trained researchers and investigators to identify the relevant research questions and also a shortage of competent and trained clinicians to deal with significant co- morbidities including diabetes, cardiovascular disease, aging and, of note, mental health issues. More recently, these gains are being eroded by the outbreak of SARS-CoV-2 infection whose impact on HIV-infected individuals particularly in our resource constrained setting remains unknown. CIDRZ, in collaboration with Washington University in St. Louis, proposes to partner with the University of Zambia, the University of Lusaka, Levy Mwanawasa Medical University, the Ministry of Health, and the National Health Research Authority to establish a training platform for ongoing high-quality HIV/ NCD research. We are requesting funding under this D71 to prepare for, and ultimately construct, a D43 that would aim to: 1. Increase the pool of qualified, competent researchers and principal investigators; 2. Increase and enhance locally-generated NCDs prevalence and risk factor data amongst HIV infected individuals; 3. develop dissemination and implementation strategies and 4. Develop collaborations with other research institutions and universities both locally and within the sub-region to leverage off current capacity and enhance the research capability.