Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network Clinical Center (Hub)

项目摘要和摘要 本附录要求支持关键活动和关键个人的努力，使大学能够 明尼苏达州警报器中心继续招募参与者参加紧急护理研究。 请求提供补充支助，以维持在前5年经常供资结束之间的业务活动 五年的警笛和第二个五年的警笛的开始。对明尼苏达枢纽的不间断支持将 确保参与者成功参加正在进行的SEREN试验(ICECAP、BOOST-3和HOBIT)， 并继续支持这些试验的辅助研究(Bio-Boost即将开始，以及Bio-HOBIT)。 在COVID大流行的高峰期，警报器研究活动暂停或严重限制在我们的 中心机构和Spoke，以及招生选项(以及支持研究团队的配套资金) 尽管Hub仍有资金需求，但往往无法获得。因此，我们预计将结束目前的 有赤字的警报器资金周期，我们将用院长办公室和一些 部门资金。然而，这些内部资金非常有限，无法支付 我们的工作将持续到下一个警报器资金周期。因此，所要求的补充资金 对于明尼苏达枢纽队不间断的表现是必不可少的。

Project Summary and Abstract This supplement requests support of key activities and effort for key individuals that will allow the University of Minnesota SIREN Hub to continue operations for recruiting participants into emergency care research. Supplemental support is requested to maintain operations between the end of regular funding for the first 5 years of SIREN and start of the second 5 years of SIREN. Uninterrupted support of the Minnesota Hub will ensure successful enrollment of participants into the ongoing SIREN trials (ICECAP, BOOST-3, and HOBIT), and the continued support for the ancillary studies for these trials (Bio-BOOST to start soon, and Bio- HOBIT). During the height of the COVID pandemic, SIREN research activities were paused or severely limited at our Hub institutions and Spokes, and enrollment options (and accompanying funds to support research teams) were often unavailable, despite continued Hub financial needs. We therefore anticipate ending the current SIREN funding cycle with a deficit, which we will cover with funding from the Dean’s office and some departmental funds. These internal funds are very limited, however, and are not available to cover the cost of the continuation of our work until the next SIREN funding cycle. Thus, the supplement funds being requested will be essential for uninterrupted Minnesota Hub performance.