Integrated Early Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder Following Sexual Assault- K23 - Supplement

摘要 拟议的以患者为导向的导师研究职业发展奖(K23)的总体目标是 支持克里斯汀·哈恩博士获得必要的技能，成为一名具有 研究计划的重点是制定酒精使用障碍(AUD)和共病的干预措施 精神健康状况，特别是创伤后应激障碍(PTSD)。AUD和创伤后应激障碍经常同时发生 在经历过创伤性生活事件的人中，例如性侵犯。然而，目前还缺乏 建立以证据为基础的干预措施，以减少最近受害者中的澳元和创伤后应激障碍。目前的研究 通过测试两种基于证据的认知-行为的新型整合，直接解决了这一临床差距 对AUD和PTSD的干预从性行为后六周开始，分五次进行 人身攻击罪。哈恩博士采用了一个由专家反馈告知的迭代过程来调整干预措施(第一阶段) 并正在进行开放标签试验(n=10)，以最终确定治疗方案(第二阶段)。在第三阶段， 治疗方案将在最近的性侵犯受害者中进行试点随机对照试验(RCT)测试 (n=54)评估在减轻AUD严重程度和PTSD症状方面的可行性和初步疗效。生态 瞬时评估(EMA)将被用来评估在五周的时间里酒精的使用、渴望和影响 治疗阶段。需要行政支持，以确保在#年期间成功实施试点RCT 分娩的关键生活事件和随后的主要照顾责任。行政支持将 用于聘请研究助理完成基本的研究任务，包括招募参与者， 管理研究评估，提供参与者报酬，并监测生态瞬时 评估数据收集。获得一名研究助理将导致更成功的招聘、登记、 和参与者完成研究。该补编将确保私募股权基金继续专注于接收 致力于指导，并实现了以下职业目标：(1)获得澳元发展机制方面的新知识 和干预；(2)培养设计和实施AUD和共生创伤后应激障碍的临床试验的技能； (3)通过多层次和纵向数据分析提高统计技能；(4)提高对 研究道德；以及(5)通过专业的手稿写作继续专业发展 演示文稿和助学金写作。哈恩博士将在南方医科大学完成K23活动 卡罗莱纳州，该州在致力于推进AUD早期调查人员方面有着良好的记录。 完成K23活动的行政支持最终将使哈恩博士准备好领导一项 严谨设计的AUD治疗结果研究。

ABSTRACT The overall objective of the proposed Mentored Patient-Oriented Research Career Development Award (K23) is to support Dr. Christine Hahn in acquiring the skills necessary to become an independent investigator with a program of research focused on the development of interventions for alcohol use disorder (AUD) and comorbid mental health conditions, in particular posttraumatic stress disorder (PTSD). AUD and PTSD frequently co-occur among people who experience traumatic life events, such as sexual assault. However, there is a lack of established evidence-based interventions to reduce AUD and PTSD among recent victims. The current study directly addresses this clinical gap by testing the novel integration of two, evidence-based, cognitive-behavioral interventions for AUD and PTSD to be delivered in five sessions beginning in the six weeks following sexual assault. Dr. Hahn adapted the intervention using an iterative process informed by expert feedback (Phase 1) and is conducting an open label trial (n = 10) to finalize the treatment protocol (Phase 2). In Phase 3, the treatment protocol will be tested in a pilot randomized controlled trial (RCT) among recent sexual assault victims (n = 54) to evaluate feasibility and preliminary efficacy in reducing AUD severity and PTSD symptoms. Ecological momentary assessments (EMA) will be used to assess alcohol use, craving, and affect during the five-week treatment phase. Administrative support is needed to ensure the pilot RCT is successfully implemented during the critical life events of childbirth and subsequent primary caretaking responsibilities. Administrative support will be used to hire a research assistant to complete essential study tasks including participant recruitment, administering study assessments, providing participant renumeration, and monitoring ecological momentary assessment data collection. Acquiring a research assistant will result in more successful recruitment, enrollment, and participant completion of the study. The supplement will ensure the PI continues to focus on receiving dedicated mentorship and achieves the following career goals: (1) Gain new knowledge in AUD mechanisms and interventions; (2) Develop skills in designing and implementing clinical trials for AUD and co-occurring PTSD; (3) Increase statistical skills with multilevel and longitudinal data analyses; (4) Enhance understanding of research ethics; and (5) Continue professional development through manuscript writing, professional presentations, and grant writing. Dr. Hahn is completing K23 activities at the Medical University of South Carolina, which has a strong track record of commitment to the advancement of early-stage AUD investigators. Administrative support to complete the K23 activities will ultimately prepare Dr. Hahn to lead a program of rigorously-designed AUD treatment outcome research.