Integrated Early Intervention for Alcohol Use Disorder and Posttraumatic Stress Disorder Following Sexual Assault

性侵犯后酒精使用障碍和创伤后应激障碍的综合早期干预

• 批准号: 10490268
• 负责人: Christine Kathryn Hahn
• 金额: $ 20.9万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10490268
• 关键词: Address; Adult; Affect; Alcohol consumption; Anxiety; Area; Back; Behavior; Behavior Therapy; Behavioral Mechanisms; Boston; Clinical; Clinical Trials; Cognition; Cognitive Therapy; Conduct Clinical Trials; Data; Data Analyses; Data Collection; Development; Early Intervention; Ecological momentary assessment; Ensure; Event; Evidence based intervention; Evidence based treatment; Exposure to; Feedback; Focus Groups; Future; Goals; Grant; Health; Health Care Costs; Impairment; Intervention; Knowledge; Lead; Life; Link; Manuscripts; Measures; Mediator of activation protein; Medical; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methods; Mission; Modification; National Institute on Alcohol Abuse and Alcoholism; Outcome; Outcomes Research; Participant; Pattern; Persons; Phase; Post-Traumatic Stress Disorders; Process; Provider; Psychotherapy; Public Health; Randomized; Randomized Controlled Trials; Reporting; Research; Research Ethics; Research Personnel; Science; Series; Severities; Site; South Carolina; Standardization; Symptoms; Testing; Time; Training; Trauma; Treatment Protocols; Treatment outcome; Universities; Woman; Writing; addiction; aged; alcohol craving; alcohol intervention; alcohol research; alcohol risk; alcohol use disorder; assault; behavior change; behavioral clinical trial; behavioral pharmacology; brief alcohol intervention; brief intervention; career; career development; clinically significant; comorbidity; craving; design; drinking; effective intervention; emotion regulation; evidence base; experience; hazardous drinking; improved; insight; intervention effect; novel; open label; patient oriented; post intervention; programs; reduce symptoms; reduced alcohol use; revictimization; service providers; sexual assault; sexual risk taking; skills; substance use; symposium; therapy development; trauma exposure; traumatic event

ABSTRACT The overall objective of the proposed Mentored Patient-Oriented Research Career Development Award (K23) is to support Dr. Christine Hahn in acquiring the skills necessary to become an independent investigator with a program of research focused on the development of interventions for alcohol use disorder (AUD) and comorbid mental health conditions, in particular posttraumatic stress disorder (PTSD). AUD and PTSD frequently co-occur among people who experience traumatic life events, such as sexual assault. There is a lack of established evidence-based interventions, however, to reduce AUD and PTSD among recent victims. The proposed study directly addresses this clinical gap by testing the novel integration of two, evidence-based, cognitive-behavioral interventions for AUD and PTSD to be delivered in five sessions beginning in the six weeks following sexual assault. In Phase 1, we will adapt the intervention using an iterative process informed by expert feedback. In Phase 2, we will conduct an open label trial (n = 10) to finalize the treatment protocol. In Phase 3, we will use the treatment protocol in a pilot randomized controlled trial among 54 recent sexual assault victims to evaluate feasibility and preliminary efficacy in reducing AUD severity and PTSD symptoms. Ecological momentary assessments (EMA) will be used to assess alcohol use, craving, and affect during the five-week treatment phase. The candidate has assembled a team of experienced mentors with expertise in AUD, PTSD, sexual assault, psychotherapy development, clinical trials, and ecological momentary assessment. On-site mentors (Drs. Sudie Back, Kathleen Brady, Michael Saladin) have extensive knowledge in developing and conducting clinical trials of behavioral and pharmacological interventions for co-occurring AUD and PTSD. Dr. Saladin has expertise in real-time data collection methods in addiction research. Off-site mentors (Dr. Barbara Rothbaum at Emory University and Dr. Brian Marx at Boston University) will provide additional guidance on early, brief interventions to reduce AUD and PTSD symptoms following sexual assault. The mentorship, formal coursework, seminars, and national conference attendance afforded by the K23 award will ensure that the candidate achieves the following career goals: (1) Gain new knowledge in AUD mechanisms and interventions; (2) Develop skills in designing and implementing clinical trials for AUD and co-occurring PTSD; (3) Increase statistical skills with multilevel and longitudinal data analyses; (4) Enhance understanding of research ethics; and (5) Continue professional development through manuscript writing, professional presentations, and grant writing. The candidate will complete the proposed K23 activities at the Medical University of South Carolina, which has a strong track record of commitment to the advancement of early stage AUD investigators. The proposed K23 activities will ultimately prepare Dr. Hahn to lead a program of rigorously-designed AUD treatment outcome research.

摘要 拟议的指导病人为导向的研究职业发展奖的总体目标 (K23)是支持克莉丝汀哈恩博士获得成为独立调查员所需的技能 一项研究计划的重点是开发酒精使用障碍（AUD）的干预措施， 合并精神健康状况，特别是创伤后应激障碍（PTSD）。AUD和PTSD经常 在经历过创伤性生活事件（如性侵犯）的人中同时发生。都缺乏 然而，建立了基于证据的干预措施，以减少最近受害者中的AUD和PTSD。的 拟议的研究通过测试两个，循证， 对AUD和PTSD的认知行为干预将在六周内开始的五次会议中进行 在性侵犯之后。在第1阶段，我们将使用专家告知的迭代过程来调整干预措施 反馈在第2阶段，我们将进行一项开放标签试验（n = 10），以最终确定治疗方案。在第三阶段， 我们将在54名最近的性侵犯受害者中进行随机对照试验， 评估降低AUD严重程度和PTSD症状的可行性和初步疗效。生态 将使用瞬时评估（EMA）来评估五周内的酒精使用，渴望和影响 治疗阶段。候选人已经组建了一个经验丰富的导师团队，他们在AUD，PTSD， 性侵犯、心理治疗发展、临床试验和生态瞬时评估。现场 导师（苏迪·巴克博士、凯瑟琳·布雷迪博士、迈克尔·萨拉丁博士）在发展和 对合并发生的AUD和PTSD进行行为和药物干预的临床试验。博士 萨拉丁在成瘾研究的实时数据收集方法方面具有专长。场外导师（芭芭拉博士 埃默里大学的罗斯鲍姆和波士顿大学的布赖恩马克思博士）将提供额外的指导， 简短的干预措施，以减少性侵犯后的AUD和PTSD症状。导师制，正式的 课程，研讨会和K23奖提供的国家会议出席将确保 候选人实现以下职业目标：（1）获得AUD机制和干预措施的新知识; (2)开发设计和实施AUD和并发PTSD临床试验的技能;（3）增加 （4）加强对科研伦理的理解; 和（5）通过手稿写作，专业演讲和资助继续专业发展 写作候选人将在南卡罗来纳州医科大学完成拟议的K23活动， 该公司在致力于促进早期AUD研究人员的发展方面有着良好的记录。的 拟议的K23活动将最终为Hahn博士领导一项严格设计的AUD治疗计划做好准备 成果研究。