Regional Biocontainment Laboratory (RBL) Upgrade for Colorado State University (CSU)

项目摘要/摘要 本补编的资金和实施对于保持不间断的研究和 科罗拉多州立大学落基山地区生物控制实验室(RMRBL)的学术活动。研究 在RMRBL发生的活动直接涉及RBL的任务，以应对和防止全球 传染病威胁。我们的努力是40多年来在CSU进行的研究的发展 主要由NIAID赞助，包括研究黄病毒科的跨学科研究小组， Togaviridae，Bunyavirales，Coronaviridae病毒病原体以及分枝杆菌的强大程序， 抗微生物耐药性，以及媒介传播的细菌病原体。RBL对于这一传染性疾病是不可或缺的 疾病研究、培训和其他学术活动。RMRBL最近受益于G20 专为急需的现代化和基础设施升级颁发的奖项。然而，这些投资 由于该设施的复杂性和高使用率，将继续需要这些设施。在这里，我们添加了具体的 我们的母公司G20奖的目标是继续进行关键投资，以改善我们的生物安全，动物 建模和成像研究的需要。

Project Summary / Abstract The funding and implementation of this supplement is essential to maintain uninterrupted research and scholarly activity in CSU’s Rocky Mountain Regional Biocontainment Laboratory (RMRBL). Research activities that occur at the RMRBL directly address the RBLs’ missions to respond to and prevent global infectious disease threats. Our efforts are the evolution of over 4 decades of research conducted at CSU predominately sponsored by NIAID, and includes interdisciplinary research teams studying Flaviviridae, Togaviridae, Bunyavirales, Coronaviridae viral pathogens along with robust programs in mycobacteria, anti microbial resistance, and vector borne bacterial pathogens. The RBL is integral for this infectious disease research, training and other scholarly activities. The RMRBL recently benefitted from a G20 award specific to much needed modernization and infrastructure upgrades. However, these investments continue to be needed due to the complexity and high use of this facility. Here, we add to the Specific Aims of our parent G20 award to continue to make critical investments to improve our biosafety, animal modeling, and imaging research needs.