Regional Biocontainment Laboratory (RBL) Upgrade for Colorado State University (CSU)

项目摘要： 意识到我们的国家和全球社区面临着故意、偶然或 一种传染病的紧急释放促使我们国家承诺投资于国家 和区域生物防护实验室作为我们公共卫生和紧急情况的一部分 准备制度。科罗拉多州立大学的山麓校园就是其中之一 洛矶山地区生物防护实验室（Rocky Mountain Regional Biocontainment Laboratory） （RMRBL）。这个实验室建于2007年，2008年开放，是12个指定实验室中的第一个。 实验室使用选定的代理人使用认证。开业14年来， 该设施作为生物防御和新兴传染病研究中心蓬勃发展， 应对结核病和新出现的传染病等疾病的威胁 疾病，如中东呼吸综合征冠状病毒，寨卡病毒，特别是严重 急性呼吸道综合征冠状病毒2.这个设施是真正独特的能力，因为它 支持BSL 3/ASBL 3和BSL 2基础研究的大量涌现和再涌现 病原体，同时支持GLP/GMP测试和产品制造 （诊断试剂、疫苗和治疗剂）。尽管RMRBL 成功和优势，完全依赖机构的承诺和服务费用， 调查员支持以下费用：（1）设施的运营和安全要求;（2） 专门用于传染病的动物护理设施和饲养;以及3）专门的 设备升级和维修，这是一个重大挑战，该设施的能力，保持在 在病原体研究的最前沿。积极主动和专业 RMRBL的管理，以及传染病研究的强大校外资金， 科罗拉多州立大学使我们能够应对这些挑战;然而， 设施老化，加上现代化和主要设施的主要费用， 专用装备升级威胁到远程导弹防御系统能力的可持续性， 最先进的传染病研究在本申请中，我们提出三个目标， 分别满足以下需求：1）提升设施的操作和安全要求， 2)保持动物护理设施和饲养专门用于传染病，和3） 通过战略投资实现专业设备的现代化。下选择的具体项目 每个目标作为关键投资，都是通过优先排序过程选择的， 主要的RMRBL和机构利益相关者，并决心产生最大的影响， 关于不间断和加速研究高密封性病原体和应对 传染病爆发。

Project Abstract: The realization that our national and global communities are at risk from intentional, incidental, or emergent release of an infectious disease catalyzed our nation's commitment to invest in national and regional biocontainment laboratories as part of our public health and emergency preparedness system. The foothills campus at Colorado State University is home to one of these regional biocontainment laboratories, the Rocky Mountain Regional Biocontainment Laboratory (RMRBL). This laboratory was built in 2007, opened in 2008, and was the first of 12 designated laboratories to operate with select agent use certification. In the 14 years since its opening, our facility has thrived as a center of biodefense and emerging infectious disease research, responding to threats from re-emergent diseases, such as tuberculosis, and emerging infectious diseases, such as Middle East Respiratory Syndrome coronavirus, Zika, and notably, Severe Acute Respiratory Syndrome Coronavirus 2. This facility is truly unique in its capacity as it supports BSL3/ASBL3 and BSL2 basic research of a large number of emerging and re-emerging pathogens, and at the same time, supports the GLP/GMP testing and manufacturing of products (diagnostic reagents, vaccines, and therapeutics) in a BSL3 environment. Despite the RMRBL's success and strengths, a sole reliance on institutional commitment and service charges to investigators to support the costs of 1) operational and safety requirements of the facility; 2) animal care facilities and husbandry dedicated to infectious diseases; and 3) specialized equipment upgrades and repairs, present a major challenge to this facility's ability to remain at the forefront of research in pathogens of high consequence. The proactive and professional management of the RMRBL, and strong extramural funding of infectious diseases research at Colorado State University have allowed us to navigate these challenges; however, the continued aging of the facility coupled with the major costs of modernization and major facility and specialized equipment upgrades threaten the sustainability of the RMRBLs capacity to support state-of-the-art infectious disease research. In this application, we propose three aims that respectively address the needs to 1) upgrade operational and safety requirements of the facility, 2) maintain animal care facilities and husbandry dedicated to infectious diseases, and 3) modernize specialized equipment via strategic investments. The specific items selected under each aim as a critical investment were selected via a prioritization process that sought input from the major RMRBL and institutional stake holders and were determined to have the greatest impact on uninterrupted and accelerated research on high-containment pathogens and response to infectious disease outbreaks.