Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival: An Integrative Approach

项目摘要：本申请是应特别利益通知(NOSI)提交的 识别为“Not-CA-22-057”。卵巢癌是北方女性最致命的妇科癌症 美国，然而我们对居住在美国的西班牙裔妇女的卵巢癌病因、复发和生存率的了解 拉丁美洲缺乏这些因素，我们对美国拉美裔女性的这些因素的了解非常有限。至 促进在未得到充分研究的全球人群中评估卵巢癌的独特发病机制， 我们将通过病历链接和集中病理审查确认卵巢癌病例，以 确定墨西哥教师队列(MTC)病例的组织类型分布并进行比较 与北加州凯撒永久医院(KPNC)的西班牙裔案件有关。我们还将确定 卵巢癌病例的临床特征、治疗方式和结果数据的可用性 在MTC中得到诊断，这有助于今后在KPNC的种族和族裔亚群之间进行比较分析。 KPNC的人口包括美国拉美裔病例，作为一个未被研究的利益群体，这 用于增加全球癌症差异研究的补充资金将支持纳入和 与居住在墨西哥的妇女中确诊的卵巢癌互补病例组的比较 来自MTC的。具体地说，我们将利用MTC现有的资源，包括CASE 为乳腺癌开发的验证链接和算法，并将它们应用于卵巢癌，以开发 评估MTC中母公司R01研究目标的子集的能力。重要的是，有能力 比较居住在加利福尼亚州的西班牙裔妇女和生活在 墨西哥12个州的地区在文化、地理和经济上的多样性将提高普适性 并提供有关研究不足和代表性不足的重要和相关数据 人口亚群。鉴于自我报告的西班牙裔种族代表着一个不同的群体， 传统和文化背景，我们还将评估所有与KPNC案件的比较 自称有墨西哥族裔的亚群。拟议研究的优点包括重叠研究 两个队列的年份(2000-2018年KPNC，2006-2022年MTC)和集中病理审查。另外， 这份增刊扩大了我们的多学科研究团队，包括更多具有专业知识的研究人员。 在互补领域，他们致力于了解卵巢癌的种族和民族差异。

Project Abstract: This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-22-057”. Ovarian cancer is the most lethal gynecologic cancer in women in North America, yet our understanding of ovarian cancer etiology, recurrence, and survival in Hispanic women living in Latin America is lacking and our understanding of these factors in US Hispanic women is very limited. To facilitate the evaluation of the unique pathogenesis of ovarian cancer among understudied global populations, we will confirm ovarian cancer cases via medical record linkage and through centralized pathology review to identify the distribution of histotypes in cases from the Mexican Teachers' Cohort (MTC) and compare them with the Hispanic cases from Kaiser Permanente Northern California (KPNC). We will also determine the availability of data on clinical characteristics, treatment patterns, and outcomes for ovarian cancer cases diagnosed in MTC that facilitate future comparative analyses across race and ethnicity subgroups in KPNC. The KPNC population includes US Hispanic cases as one understudied group of interest and this supplemental funding to increase global cancer disparities research will support the inclusion of and comparison with a complementary group of ovarian cancer cases diagnosed among women living in Mexico from the MTC. Specifically, we will leverage the existing resources available in the MTC, including case validation linkages and algorithms developed for breast cancer, and apply them to ovarian cancer, to develop the capacity to evaluate a subset of the parent R01 research aims in the MTC. Importantly the ability to compare histotype distributions and survival of Hispanic women living in California to women living in a culturally, geographically, and economically diverse 12-state region in Mexico will improve the generalizability of our study findings and provide important and relevant data on an understudied and underrepresented population subgroup. Given that self-reported Hispanic ethnicity represents a diverse group with varying traditions and cultural backgrounds, we will also evaluate all comparisons with KPNC cases among the subgroup with self-reported Mexican ethnicity. Strengths of the proposed study include the overlapping study years for the two cohorts (2000-2018 KPNC, 2006-2022 MTC) and centralized pathology review. Additionally, this supplement expands our multi-disciplinary research team to include additional researchers with expertise in complementary areas who are committed to understanding racial and ethnic disparities in ovarian cancer.