Data Management and Analysis Core

摘要 数据管理和分析核心(DMAC)旨在为数据提供共享资源 跨项目管理和分析，并促进数据和分析的集成和共享 资源。通过集中这些活动，我们将确保每个项目产生的数据的完整性， 通过共享数据和分析资源提高效率，并提供生物统计咨询 结合了肺纤维化病因学的深入知识。这一战略还将使我们能够协调 研究设计和数据管理问题，导致更一致的数据分析方法以及 显著节省成本核心领导(Peljto)将监督一个在进行研究方面经验丰富的团队 涉及多学科研究。团队还拥有管理复杂研究问题所需的技能 设计、多方面的数据库管理、基因组学和广泛的定量方法。的主要活动 DMAC将1)提供研究设计咨询和改进，2)提供安全的中央存储库 并对生成的数据进行质量控制，3)进行生物统计和生物信息学分析，以检验提出的 假设4)促进项目数据和分析资源的集成和共享。这些活动将 通过研究、设计、咨询和分析，直接服务于所有四个项目。此外，DMAC将工作 与核心B和C密切合作，以传输、注释和存储为每个项目生成的数据和数字图像。 最后，这一核心将与行政核心协调，因为它提供行政和组织 结构来支持这一计划，并将接受管理核心的指示。此核心将与 与行政核心和项目调查员举行定期会议，以便佩尔托博士和 适当的DMAC成员将与单个项目团队或整个计划会面。这些 核心的活动将协助所有项目和行政核心完成其研究、报告、 和资源共享的目标和义务

ABSTRACT The Data Management and Analysis Core (DMAC) is designed to provide a shared resource for data management and analysis across projects, and to facilitate the integration and sharing of data and analytic resources. By centralizing these activities, we will ensure the integrity of the data produced by each project, create efficiencies through sharing of data and analytic resources, and provide biostatistical consultation that incorporates an in-depth knowledge of pulmonary fibrosis etiology. This strategy will also allow us to coordinate study design and data management issues, leading to a more coherent approach to data analysis, as well as significant cost savings The Core Lead (Peljto) will supervise a team that is experienced in the conduct of studies involving multidisciplinary research. The team also has the skill set required to manage complex issues of study design, multifaceted database management, genomics, and broad quantitative methods. The key activities of the DMAC will be 1) providing study design consultation and refinement, 2) providing a secure, central repository and quality control for data generated, 3) conducting biostatistical and bioinformatics analyses to test proposed hypotheses 4) facilitating integration and sharing of Project data and analytic resources. These activities will directly serve all four projects through study design consultation and analysis. In addition, the DMAC will work closely with Cores B and C to transfer, annotate, and store data and digital images generated for each Project. Finally, this Core will coordinate with the Administrative Core, as it provides the administrative and organizational structure to support this Program, and will receive direction from the Administrative Core. This Core will interact with the Administrative Core and Project Investigators at regular meetings, such that each week Dr. Peljto and appropriate DMAC members will meet with either an individual Project team or the entire Program. These activities of the Core will assist all of the Projects and the Administrative Core in fulfilling their research, reporting, and resource sharing goals and obligations