Training in Basic and Translational Digestive Sciences

摘要 本申请旨在更新NIH T32基础和转化消化科学培训， 目前已进入第10个年头。密歇根大学在胃肠病学方面有着悠久的历史， 在过去的几十年里，科学，包括医生和非医生科学家。2012年我们 启动了一项培训计划，重点是培养博士后临床研究员（MD，MD/PhD）， 对基础和转化消化科学感兴趣的博士前博士候选人科学家。培训 该计划包括26名NIH资助的教师导师，其中包括12名临床活跃的医生科学家和14名非 临床教员，来自临床和基础科学部门：内科（13）， 分子与综合生理学（6），病理学（3），微生物学与免疫学（3）和外科学（1）。我们 该计划巩固了正在进行胃肠道基础和翻译的主要研究人员 密歇根大学医学院的研究成为医生培训导师的强大核心 科学家和生物医学研究人员对胃肠道科学的研究事业感兴趣。我们这群 26名培训项目教师也是由NIH资助的密歇根消化疾病核心中心的成员 (P30 DK 34933）自1986年以来，带来了合作和团队科学的悠久历史。我们的T32培训 该计划侧重于三个主题领域，这些领域提供了卓越的跨学科合作， 参与能力：1）细胞命运、可塑性、再生和转化的机制; 2）系统性， 细胞和营养代谢; 3）对宿主-环境-微生物的免疫和炎症反应 交互.要求继续支持3名博士前实习生在多个国家之一寻求博士学位， 学科范围从生理学，微生物学和免疫学，细胞和分子生物学，并为2 胃肠病学博士后研究生。该计划由Chung Owyang，MD（ 胃肠病学，内科）和琳达萨缪尔森，博士（分子和生物学系） 综合生理学），包括每周一次的GI科学系列研讨会（内部和外部演讲者）， 学员研究演示，负责任的研究行为和研究再现性的培训，以及 强有力的辅导和职业发展指导。实习生研究将得到20多美元的支持 每年向培训学院提供的研究经费达100万美元， 支持直接支持学员和计划。现有生物的总量和多样性 资源，我们过去的培训记录，以及培训教师的卓越表现提供了强大的 有证据表明，该计划将继续在培训下一代调查人员方面取得巨大成功 对基础和转化消化科学感兴趣。

ABSTRACT This application seeks to renew the NIH T32 Training in Basic and Translational Digestive Sciences that is currently in its 10th year. The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades, including both physician and non-physician scientists. In 2012 we initiated a training program that focused on training postdoctoral clinical fellows (MD, MD/PhD) together with predoctoral PhD candidate scientists interested in basic and translational digestive sciences. The Training Program includes 26 NIH-funded faculty mentors, including 12 clinically active physician scientists and 14 non- clinical faculty members, who come from clinical and basic science departments: Internal Medicine (13), Molecular & Integrative Physiology (6), Pathology (3), Microbiology & Immunology (3), and Surgery (1). Our program consolidates the major investigators who are conducting gastrointestinal basic and translational research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in a research career in gastrointestinal science. Our group of 26 training program faculty are also members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986 and bring a long history of collaboration and team science. Our T32 training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) mechanisms of cell fate, plasticity, regeneration, and transformation; 2) systemic, cellular, and nutrient metabolism; 3) immune and inflammatory responses to host-environment-microbial interactions. Continued support is requested for 3 predoctoral trainees seeking PhDs in one of a number of disciplines that range from Physiology, Microbiology & Immunology, to Cell & Molecular Biology, and for 2 postdoctoral Gastroenterology Fellow trainees. The Program, co-directed by Chung Owyang, MD (Division of Gastroenterology, Department of Internal Medicine) and Linda Samuelson, PhD (Department of Molecular & Integrative Physiology), includes a weekly seminar series in GI science (both internal and external speakers), trainee research presentations, training in responsible conduct of research and research reproducibility, and strong mentoring and career development guidance. Trainee research will be supported by more than $20 million of annual research funding awarded to the training faculty combined with substantial institutional support to directly support the trainees and the Program. The combined mass and diversity of available resources, our past training record, and the demonstrated excellence of the training faculty provide strong evidence that this program will continue to be highly successful in training the next generation of investigators interested in basic and translational digestive sciences.