Nausea, Vomiting, and Diarrhea Are Common in Community-Acquired Acute Viral Respiratory Illness.
Nausea, Vomiting, and Diarrhea Are Common in Community-Acquired Acute Viral Respiratory Illness.
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DOI：
10.1007/s10620-023-07976-4
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发表时间：
2023-08
影响因子：
3.1
通讯作者：
Seattle Flu Study Investigators
中科院分区：
文献类型：
--
作者：
Newman, Kira L. R.;Wolf, Caitlin R. K.;Logue, Jennifer K. A.;Englund, Janet A.;Boeckh, Michael Y.;Chu, Helen Y.;Seattle Flu Study Investigators
胃肠道（GI）症状是公认的急性呼吸道疾病（ARI）的后遗症，但其患病率没有很好的记录。我们的研究目的是评估所有年龄段人群的社区ARI病例中GI症状的发生率及其与临床结局的相关性。我们在2018-2019冬季收集了西雅图地区个体的中鼻拭子，临床和症状数据，作为大规模前瞻性社区监测研究的一部分。通过聚合酶链反应（PCR）检测拭子中的26种呼吸道病原体。采用Fisher精确检验、Wilcoxon秩和检验、t检验和多变量logistic回归分析了给定人口统计学、临床和微生物协变量的GI症状的可能性。在3183次ARI发作中，29.4%有GI症状（n = 937）。胃肠道症状与病原体检测、疾病干扰日常生活、寻求疾病护理和更大的症状负担显著相关（所有p < 0.05）。控制年龄、> 3种症状和月份，流感（p < 0.001）、人偏肺病毒（p = 0.004）和肠道病毒D 68（p = 0.05）与GI症状的相关性显著高于未检测到病原体的发作。季节性冠状病毒（p = 0.005）和鼻病毒（p = 0.04）与胃肠道症状相关性显著降低。在这项ARI的社区监测研究中，GI症状很常见，并与疾病严重程度和呼吸道病原体检测相关。GI症状未追踪已知的GI嗜性，表明GI症状可能是非特异性的，而不是病原体介导的。出现胃肠道和呼吸道症状的患者应进行呼吸道病毒检测，即使呼吸道症状不是主要问题。在线版本包含补充材料，可通过10.1007/s10620-023-07976-4获得。
Gastrointestinal (GI) symptoms are recognized sequelae of acute respiratory illness (ARI), but their prevalence is not well documented. Our study aim was to assess the incidence of GI symptoms in community ARI cases for persons of all ages and their association with clinical outcomes. We collected mid-nasal swabs, clinical, and symptom data from Seattle-area individuals during the 2018–2019 winter season as part of a large-scale prospective community surveillance study. Swabs were tested by polymerase chain reaction (PCR) for 26 respiratory pathogens. Likelihood of GI symptoms given demographic, clinical, and microbiological covariates were analyzed with Fisher’s exact, Wilcoxon-rank-sum, and t-tests and multivariable logistic regression. In 3183 ARI episodes, 29.4% had GI symptoms (n = 937). GI symptoms were significantly associated with pathogen detection, illness interfering with daily life, seeking care for the illness, and greater symptom burden (all p < 0.05). Controlling for age, > 3 symptoms, and month, influenza (p < 0.001), human metapneumovirus (p = 0.004), and enterovirus D68 (p = 0.05) were significantly more likely to be associated with GI symptoms than episodes with no pathogen detected. Seasonal coronaviruses (p = 0.005) and rhinovirus (p = 0.04) were significantly less likely to be associated with GI symptoms. In this community-surveillance study of ARI, GI symptoms were common and associated with illness severity and respiratory pathogen detection. GI symptoms did not track with known GI tropism, suggesting GI symptoms may be nonspecific rather than pathogen-mediated. Patients presenting with GI and respiratory symptoms should have respiratory virus testing, even if the respiratory symptom is not the primary concern. The online version contains supplementary material available at 10.1007/s10620-023-07976-4.
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影响因子：
3.7
作者：
Qiu FZ;Shen XX;Li GX;Zhao L;Chen C;Duan SX;Guo JY;Zhao MC;Yan TF;Qi JJ;Wang L;Feng ZS;Ma XJ
通讯作者：
Ma XJ
影响因子：
3.7
作者：
Minodier L;Masse S;Capai L;Blanchon T;Ceccaldi PE;van der Werf S;Hanslik T;Charrel R;Falchi A
通讯作者：
Falchi A
影响因子：
6.4
作者：
Shu, Yuelong;Li, Chris Ka-fai;Xu, Xiao-Ning
通讯作者：
Xu, Xiao-Ning
影响因子：
11.8
作者：
Cheng, Wei-xia;Jin, Yu;Fang, Zhao-yin
通讯作者：
Fang, Zhao-yin
影响因子：
11.8
作者：
Wang, Claire Y. T.;Ware, Robert S.;Bialasiewicz, Seweryn
通讯作者：
Bialasiewicz, Seweryn