Scientist Training in Rheumatology Research

项目摘要/摘要 这项申请是密歇根大学科学家培训计划的竞争性更新 风湿病研究(T32AR007080)。我们的计划自1975年以来由NIAMS资助，旨在 每年培养四名杰出的博士后科学家，包括医学博士和博士，从事研究工作 与风湿病相关的研究。我们的计划是由几个关键因素推动的，包括(I) 风湿病的无情负担造成的巨大临床需求；(Ii)认识到 风湿性疾病是由需要多学科方法的复杂过程推动的；以及 受到威胁的不同研究人员致力于风湿病研究的职业 研究。幸运的是，最近生物医学和临床科学的进步创造了前所未有的 更深入地了解疾病病因并最终改善结果的研究机会 通过个性化的方法照顾每个患有风湿病的人。我们的22个 项目教师导师是专注于研究人员的导师，他们共同带来了广泛的跨学科 专注于风湿病的专业知识。这些调查人员建立了广泛的合作关系 国内和国际研究单位有效研究风湿病发病机制并改进 管理层。利用这些历史优势，我们计划的主题已更新，以与 NIAMS的战略使命是通过交叉的科学研究超越疾病和组织的界限 主题。“在我们计划即将到来的周期中，主要的科学主题将包括：(I)生物学基础 临床异质性；(Ii)疾病的免疫学机制；(Iii)损伤、修复和纤维化；以及(Iv) 患者结果/体验和创新试验。学员还被提供了强大的道德根基 开展研究，并拥抱多样性、公平和包容的文化。一些额外的 培训方案的重点包括：(1)提供获奖的为期10周的研究培训 为对基础研究有浓厚兴趣的见习医生开设的课程；(Ii)为见习医生提供多种途径 在项目培训的同时获得硕士学位，以及(Iii)杰出的最先进的生物医学 提供与密歇根大学顶尖地位相称的培训、咨询和科学服务的核心 美国的公共研究机构。培训是我们节目的长期使命 来自不同背景的人从事研究工作。自2009年以来的26名学员中，有17名(65%)是 女性和8人(31%)来自代表性不足的背景(1名黑人，5名西班牙裔或拉丁裔，以及 2来自弱势背景)；目前的受训人员中有一半认为代表不足的少数群体。的 自2011年以来参加我们项目的20名学员(9名医学博士和11名博士)，均为20人 继续参与研究。20人中有14人(70%)从事研究密集型职业，10人 成功争取赠款资金(约有70笔赠款被授予该小组，作为国际和平协会)。

PROJECT SUMMARY / ABSTRACT This application is a competitive renewal of the University of Michigan's Program for Scientist Training in Rheumatology Research (T32AR007080). Our Program, funded by NIAMS since 1975, is designed to prepare four outstanding postdoctoral scientists per year, both MD and PhD, for investigative careers in research related to the rheumatic diseases. Our Program is motivated by several key factors including (i) the tremendous clinical need caused by the unrelenting burden of rheumatic diseases; (ii) an appreciation that rheumatic diseases are propelled by complex processes in need of multidisciplinary approaches; and (iii) a threatened pipeline of diverse investigators committed to careers that will be devoted to rheumatology research. Fortunately, recent advances in biomedical and clinical sciences have created unprecedented research opportunities to understand disease etiologies more deeply—and ultimately improve outcomes through an approach personalized to the care of each individual living with a rheumatic disease. Our 22 Program faculty mentors are dedicated researcher-mentors who together bring broad interdisciplinary expertise focused on rheumatic diseases. These investigators have established extensive collaborations with research units nationally and internationally to effectively study rheumatic disease mechanisms and improve management. Leveraging these historical strengths, our Program's themes have been updated to align with NIAMS strategic mission “to transcend disease- and tissue-specific boundaries via cross-cutting scientific themes.” For the upcoming cycle of our Program, major scientific themes will include (i) Biologic Underpinnings of Clinical Heterogeneity; (ii) Immunological Mechanisms of Disease; (iii) Injury, Repair, and Fibrosis; and (iv) Patient Outcomes/Experience and Innovative Trials. Trainees are also provided strong roots in the ethical conduction of research, and in embracing a culture of diversity, equity, and inclusion. Some additional highlights of the Training Program include: (i) the availability of an award-winning 10-week research training course offered to physician trainees with a strong interest in basic research; (ii) multiple paths for trainees to earn a master's degree concurrent with their Program training, and (iii) outstanding state-of-the-art biomedical cores that provide training, consultations, and scientific services commensurate with U-M's standing as the top public research institution in the United States. It has been a longstanding mission of our Program to train individuals from diverse backgrounds for careers in research. Of the 26 trainees since 2009, 17 (65%) are women and eight (31%) come from underrepresented backgrounds (1 Black, 5 Hispanic or Latinx, and 2 from disadvantaged backgrounds); half of the current trainees identify as underrepresented minorities. Of the 20 trainees (9 MD and 11 PhD) who have completed their participation in our Program since 2011, all 20 remain involved in research. Fourteen of the 20 (70%) are working in research-intensive careers, and ten have successfully competed for grant funding (~70 grants have been awarded to the group as PI).