Administration Core

行政核心-摘要 在几乎所有非生殖组织类型中，男性比女性更容易患癌症。膀胱癌 这种性别偏见现象的典型表现是男性对女性的风险比在死亡率中排名第一，在发病率中排名第二。 即使在调整了其他已知的风险因素后，这种男性偏好仍然存在，这支持了一个基本面 生物学过程是两性异形的基础。该计划项目补助金（PPG）的总体目标是 阐明膀胱癌性别偏倚发病率和死亡率的分子和细胞机制 癌行政核心（Admin Core）为整体科学方向和计划提供领导 监督和行政，财政和项目的所有研究活动的组织协调， 共享资源核心。管理核心的具体目标如下。目标1：领导 全面的科学指导和项目监督。这包括制定研究议程，重点是 推进对膀胱癌性别差异的基本认识。行政核心将监督方案 活动包括科学完整性、数据管理和确保数据完整性以及直接支出。 目标2：促进PPG调查人员和资源核心领导人的沟通和整合。在 除了每月定期的虚拟和面对面的进度更新和沟通外，管理核心还将 通过频繁和有意的互动，促进建设性的审查和加强研究进展 通过内部和外部科学咨询委员会与主题专家合作。目标3：提供全面的 行政和财政管理支助。这包括确保遵守所有条款和条件 拨款，并咨询和沟通与校外NCI/NIH工作人员在提交所有必要的内部 外部研究报告。行政核心还将制定和监测纳入妇女的政策 和少数民族在膀胱癌的性别差异相关的研究。

ADMINISTRATIVE CORE – SUMMARY Men are more likely to develop cancer than women in nearly every non-reproductive tissue type. Bladder cancer typifies this sex-bias phenomenon as the male-to-female risk ratio ranking 1st in mortality and 2nd in incidence. This male-bias persists even after adjustment for other known risk factors, supporting the idea that a fundamental biological process(es) underlies sexual dimorphism. The overall goal of this Program Project Grant (PPG) is to elucidate the molecular and cellular mechanisms underlying sex-biased incidence and mortality seen in bladder cancer. The Administrative Core (Admin Core) provides the leadership for overall scientific direction and program oversight and administrative, fiscal, and organizational coordination of all research activities of Projects and shared Resource Cores. The Specific Aims of the Admin Core are as follows. Aim 1: To provide leadership for overall scientific direction and program oversight. This includes setting the research agenda focused on advancing basic understanding of sex differences in bladder cancer. The Admin Core will oversee programmatic activities including scientific integrity, data management and ensuring data integrity, and direct expenditures. Aim 2: To facilitate communication and integration of the PPG investigators and Resource Core leaders. In addition to regular monthly virtual and in-person progress updates and communications, the Admin Core will facilitate constructive review and enhancement of research progress through frequent and deliberate interactions with subject matter experts via Internal and External Scientific Advisory Committees. Aim 3: To provide overall administrative and fiscal management support. This includes ensuring compliance with all terms and conditions of the grant, and consulting and communicating with extramural NCI/NIH staff in submitting all necessary internal and external research reports. The Admin Core will also establish and monitor policies for inclusion of women and ethnic minorities in research related to sex differences in bladder cancer.