Research Training in Gastrointestinal and Hepatic Diseases

项目摘要 基础生物医学、临床和转化科学的发现步伐不断加快， 前所未有的机会，改变病人的护理在胃肠道和肝脏疾病。在过去35 多年来，布里格姆妇女医院（BWH）为学术培训做出了重大贡献。 胃肠病学家和肝病学家寻求治疗消化系统疾病。BWH的这份申请 请求支持BWH对4名基础和临床/转化研究员进行研究培训 为额外的培训提供资金。兴趣浓厚、扎实的优秀候选人 将招募和培训研究基金会成员，以运用他们的知识和技能解决 在预防、诊断和治疗胃肠道疾病和 肝脏疾病学员将获得为期2年的计划支持，在此期间，他们将遵循一个结构化的 严格但个性化的训练计划这将是25个杰出和多样化的联合努力， 来自BWH、波士顿儿童医院、达纳法伯癌症研究所、哈佛医学院、 哈佛T. H.公共卫生学院、马萨诸塞州理工学院和布罗德研究所。 这些导师组成了一个合作研究人员网络，他们是各个领域的国际领导者。 与胃肠病学和肝病学直接相关。它们被分为四个主题，但 相互关联的研究培训单位：细胞生物学，免疫学和微生物学;新陈代谢和 生物工程;基因、干细胞和发展;以及临床和转化科学。这些培训 各单位将提供针对具体内容的教育节目，并将提高行政效率 在训练计划中。监督将由一个研究培训执行委员会提供，包括 项目主任和2名副项目主任，他们也将担任导师。额外 成员将提供指导，指导如何在培训中实现和保持多样性 程序.一个优秀的内部和外部顾问委员会成员名册将评估该计划， 提供具体建议，以提高其质量，多样性，效率和研究增值 培养我们最有前途的胃肠病学研究员这一高度个性化的培训计划将包括： 1)个人发展计划; 2）严格的研究培训; 3）尖端实践经验 方法;（4）综合课程。学员将进一步受益于广泛的机构培训， 参与机构的资源和丰富的知识环境。根据持续的 在我们的奖学金计划的兴趣，我们预计高素质的候选人，并将 保持对多样性的高度重视。通过其严格，结构化和高度个性化的课程， 培训计划肯定了其致力于培养未来的领导人在消化系统疾病研究谁是 准备将他们的发现转化为改善病人护理。

PROJECT SUMMARY The accelerating pace of discovery in the basic biomedical, clinical and translational sciences now provides unprecedented opportunities to transform patient care in gastrointestinal and liver diseases. Over the past 35 years, Brigham and Women’s Hospital (BWH) has made major contributions to the training of academic gastroenterologists and hepatologists seeking cures for digestive diseases. This application from BWH requests support for the research training of 4 basic and clinical/translational research fellows, with BWH providing funding for an additional training slot. Outstanding candidates with strong interests and solid foundations in research will be recruited and trained to apply their knowledge and skills towards addressing important unmet clinical needs in the prevention, diagnosis, and treatment of patients with gastrointestinal and hepatic diseases. Trainees will receive program support for 2 years during which they will follow a structured and rigorous, but individualized training program. This will be a joint effort of 25 eminent and diverse preceptors from BWH, Boston Children’s Hospital, Dana Farber Cancer Institute, Harvard Medical School, the Harvard T.H. Chan School of Public Health, Massachusetts Institute of Technology and the Broad Institute. These preceptors constitute a network of collaborative researchers, who are international leaders in fields directly relevant to gastroenterology and hepatology. They have been organized into 4 themed, but interconnected research training units: cell biology, immunology and microbiology; metabolism and bioengineering; genes, stem cells and development; and clinical and translational sciences. These training units will provide content-specific educational programming and will increase the efficiency of administration within the training program. Oversight will be provided by a Research Training Executive Committee including the Program Director and 2 Associate Program Directors, who will also serve as preceptors. Additional members will provide guidance on mentoring and on achieving and maintaining diversity within the training program. An outstanding roster of internal and external advisory board members will evaluate the program and provide specific recommendations that improve its quality, diversity, efficiency and value added to the research training of our most promising gastroenterology fellows. This highly personalized training program will include: 1) individual development plans; 2) rigorous research training; 3) hands-on experience in cutting-edge methodologies, and; 4) an integrated curriculum. Trainees will further benefit from the extensive institutional resources and rich intellectual environment of the participating institutions. Based upon the sustained levels of interest in our fellowship program, we anticipate a substantial pool of highly qualified candidates and will maintain a strong focus on diversity. Through its rigorous, structured and highly personalized curriculum, this training program affirms its commitment to training future leaders in digestive disease research who are prepared to translate their findings towards improving patient care.