Exploring affect-motivated alcohol use as a value-based decision-making process

项目总结/摘要 K99培训：拟议的K99/R 00独立之路奖的目标是为乔纳斯博士提供 多拉接受了作为一名独立科学家的职业生涯所需的培训。在获得认知科学博士学位后， 多拉博士已经开始对酒精使用研究领域做出重要贡献 作为华盛顿大学心理学系的博士后研究员。的 拟议的K99培训期建立在Dora博士的博士背景和他目前在研究 酒精在自然环境中的作用K99阶段将提供一段时间的强化培训， 用实验、生态学瞬时评估和计算方法研究酒精使用， 并将使多拉博士在2010年期间为酒精研究领域做出实质性贡献。 他的事业Dora博士将向建议的导师（Kevin King博士）、当地合作者（William博士） 乔治，玛丽拉里默）和外部合作者（马特菲尔德博士，詹姆斯墨菲，凯蒂Witkiewitz），谁是 使用实验和生态有效方法进行酒精使用研究领域的领先专家， 以及行为和主观数据的高级计算建模。此外，Dora博士将 参加课程、科学会议和讲习班，以实现其培训目标。大学 华盛顿是一个世界级的研究机构，提供了最佳的环境，必要的 资源和激励的智力空间，以促进成功完成这个项目。 K99研究：Dora博士将与他的导师和合作者一起，在一个 模拟酒吧环境以及在人们自然饮酒环境中的研究，以验证这种想法， 酒精的负强化和正强化可以观察到， 酒精使用障碍（AUD）的症状在酒精和无物质酒精之间做出决定。 R 00研究：Dora博士将使用一项涉及以下假设选择的任务来翻译K99研究： 酒精和无物质的酒精饮料进入生态有效的假设测试， 消极影响不同地激励现实世界中基于价值的饮酒决策（与调节影响 通过替代情绪调节策略）在日常生活中有/无AUD症状的重度饮酒者中进行。 意义：本研究结合认知心理学和酒精使用研究的方法， 提供了一个新的测试的想法，酒精使用是加强在面对积极和消极的情绪， 这样将推进NIAAA战略目标，即确定有助于AUD的机制。通过研究 酒精使用作为一种基于价值的决策形式，从这个项目的见解将建议新的 在预防和治疗酒精使用障碍中针对人们的情绪的可能性。

PROJECT SUMMARY/ABSTRACT K99 training: The goal of the proposed K99/R00 Pathway to Independence Award is to provide Dr. Jonas Dora with training needed to launch his career as an independent scientist. Following his PhD in cognitive psychology, Dr. Dora has already started to make important contributions to the field of alcohol use research as a postdoctoral research fellow in the Department of Psychology at the University of Washington. The proposed K99 training period builds on Dr. Dora’s PhD background and his current training in the study of alcohol use in natural environments. The K99 phase will provide a period of intensive training in the combined study of alcohol use with experimental, ecological momentary assessment, and computational approaches, and will position Dr. Dora to make substantial contributions to the field of alcohol research over the course of his career. Dr. Dora will learn from the proposed mentor (Dr. Kevin King), local collaborators (Drs. William George, Mary Larimer) and external collaborators (Drs. Matt Field, James Murphy, Katie Witkiewitz), who are leading experts in the field of alcohol use research using both experimental and ecologically valid approaches, as well as the advanced computational modeling of behavioral and subjective data. In addition, Dr. Dora will attend courses, scientific conferences, and workshops to meet his training objectives. The University of Washington is a world-class research institution that provides an optimal environment, the necessary resources, and a stimulating intellectual space to facilitate successful completion of this project. K99 research: Together with his mentor and collaborators, Dr. Dora will conduct controlled experiments in a simulated bar environment as well as studies in people’s natural drinking environment to test the idea that negative and positive reinforcement of alcohol can be observed when heavy drinkers with and without symptoms of alcohol use disorder (AUD) make decisions between alcohol and substance-free reinforcers. R00 research: Dr. Dora will translate the K99 research using a task involving hypothetical choices between alcohol and substance-free reinforcers into an ecologically valid test of the hypothesis that positive and negative affect differentially motivate real-world value-based decisions to consume alcohol (vs regulate affect via alternative emotion regulation strategies) in heavy drinkers with/without symptoms of AUD in everyday life. Significance: By combining methods from cognitive psychology and alcohol use research, this research will provide a novel test of the idea that alcohol use is reinforcing in the face of positive and negative emotions, and in that way will advance NIAAA’s strategic aim to identify mechanisms that contribute to AUD. By studying alcohol use as a form of value-based decision-making, the insights from this project will suggest new possibilities to target people’s emotions in the prevention and treatment of alcohol use disorder.